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계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children’s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination. (Allergy Asthma Respir Dis 2013;1:333-338)
계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children`s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
김수연 ( Soo Yeon Kim ),김정윤 ( Jung Yoon Kim ),한윤기 ( Yoon Ki Han ),김종덕 ( Jong Deok Kim ),설인숙 ( In Suk Sol ),박영아 ( Young A Park ),김윤희 ( Yoon Hee Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한소아알레르기호흡기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.3
Purpose: Exhaled breath temperature (EBT) has been suggested as a noninvasive marker of airway inflammation in asthma. The aim of this study was to determine its clinical implication in children with asthma. Methods: A total of 233 children were enrolled in this study. Among them, 116 were asthmatic children and 117 were healthy children. Spirometry, bronchodilator response (BDR) test, methacholine challenge test, and skin prick test were performed. EBT, frac-tional exhaled nitric oxide (FeNO), blood eosinophils, and total IgE levels were measured. EBT was measured by using X-halo. Results: EBT was significantly higher in the asthma group than in the control group (median [interquartile range], 32.1°C [30.0°C- 33.9°C] vs. 29.7°C [29.0°C-31.3°C], P<0.001). EBT was significantly higher in poorly or partly controlled asthmatic children than well-controlled asthmatic children (33.5°C [31.0°C-34.4°C] vs. 30.3°C [29.3°C-32.9°C], P<0.0001). Among total subjects, EBT was significantly higher in the atopic group than in the nonatopic group (32.4°C [30.3°C-34.0°C] vs. 29.8°C [29.0°C-30.3°C], P<0.001). There were neither significant associations between EBT and BDR (r=0.109, P=0.241) nor between EBT and PC20 (provocation concentra-tion causing a 20% fall in FEV1) in total subjects (r=0.127, P=0.316). EBT did not show any association with FeNO (r=0.353, P=0.071). Conclusion: Our study suggests that EBT might play a role as an ancillary marker for allergic airway inflammation and the degree of control in pediatric asthma patients. Additional studies are required to explore the value of EBT in detail. (Allergy Asthma Respir Dis 2017;5:147-152)
응급실 내원 소아청소년에서 심한 식품알레르기의 발생 빈도와 임상 특징
이수영 ( Soo Young Lee ),김경원 ( Kyun Won Kim ),이현희 ( Hyun Hee Lee ),임대현 ( Dae Hyun Lim ),정혜리 ( Hae Lee Chung ),김성원 ( Sung Won Kim ),이소연 ( So Yeon Lee ),양은석 ( Eun Seok Yang ),이정민 ( Jeong Min Lee ),김규언 ( Ky 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.3
Background: Incidence and severity of childhood food allergy increased during the past 2 decades and that pediatric emergency department visits and death occurring due to food-induced anaphylaxis also increased in Western countries. Methods: To evaluate the incidence and clinical characteristics of pediatric emergency department visits due to severe forms of food allergy in Korea, data were collected from 305 with urticaria, angioedema or anaphylaxis of 78,889 children aged ≤18 or younger than 18 years who visited the emergency departments between of 9 hospitals in 8 cities in Korea June 2008 and March 2009. The incidence and clinical characteristics of childhood food allergy were evaluated using the detailed medical records. Results: Of 78,889 children, 169 (0.214%) showed food-related systemic urticaria, angioedema or anaphylaxis. Of the 57 children with anaphylaxis, 36 of which (63.16%) were food-related. The incidence of food-related anaphylaxis was 4.56 per 10,000 pediatric emergency department visits. Cutaneous symptoms (92.8%) were the most common anaphylaxis followed by cardiovascular (29.82%), gastrointestinal (28.07%), and respiratory symptoms (24.56%). The most common offending food allergen was fish, followed by cow`s milk, other seafoods, chicken, pork, egg, walnut, pupa, peanut, beef and buckwheat. There were no cases of death from anaphylaxis in this study. Conclusion: This is the first study to evaluate the incidence of pediatric emergency department visits and severity of childhood food allergy in Korea. The causative food allergens and clinical characteristics of pediatric emergency department visits due to food allergy in Korean children have been surveyed.