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- 저자 : 권삼옥 (검색결과 3 건)
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두경부 종양과 경부 임파절 전이 : 갈륨 스캔과 CT 소견의 비교
권삼옥 대한영상의학회 1995 대한영상의학회지 Vol.33 No.5
Purpose : To assess relative diagnostic value of Ga-67 planar, Ga-67 SPECT, and CT images for detection ofhead and neck tumors and cervical lymph node metastasis. Materials and Methods : Thirty eight patients ofpathologically proven head and neck tumors including squamous cell carcinomas(n=32), malignant lymphomas(n=3),undifferentiated carcinomas(n=2), adenocarcinomas(n=1) were enrolled in this study. Ga-67 planar and SPECT imageswere obtained with intravenous injection of 5mCi of Ga-67 citrate. On the basis of 30 and 20mm in the greatestdiameter of cervical lymph nodes, we compared lesion detectability of Ga-67 planar, SPECT, and CT. Results :Thirty eight cases of head and neck tumors were detected in 29 cases(76.3%) with Ga-67 planar image, 37cases(97.3%) with Ga-67 SPECT, and 32 cases(84.2%) with CT. 25 of 32 squamous cell carcinomas were positive withGa-67 planar image and all of 32 cases with Ga-67 SPECT. Both of two undifferentiated carcinomas were positivewith Ga-67 planar and SPECT images. Two of three malignant lymphomas were positive with Ga-67 planar image and allof three with Ga-67 SPECT. Eight of nine tumors were negative with Ga-67 planar image and those were less than30mm. One case of adenocarcinoma was negative with Ga-67 planar and SPECT images. Seven of nine lymph nodesgreater than 30mm were positive with Ga-67 planar image and all of nine with Ga-67 SPECT. On the basis of 20mm ingreatest diameter, 16 of 21 lymph nodes greater than 20mm were positive with Ga-67 planar and SPECT images.Conclusion : CT providing better resolution than Ga-67 scan permitted analysis of size and location of metastaticcervical nodes, however primary tumors of oral cavity, vocal cord, and nasopharynx were often not detected on CTwhen metallic and motion artifacts were present, where Ga-67 SPECT was useful. Ga-67 SPECT enabled betteranatomical localization than Ga-67 planar image and was useful in detection of lymph nodes greater than 30mm.
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급성 주정 중독 흰쥐에서 간의 Aryl sulfotransferase and UDP-Glucuronosyltransferase 활성에 미치는 총담관 결찰의 영향
권삼옥,김여희 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2
The activities of aryl sulfotransferase (AST) isozymes Ⅰ-Ⅱand Ⅲ-Ⅳand UDP-glucuronosyltransferase (UDP-GT) were measured in rats with acute ethanol intoxication after common bile duct(CBD) ligation to investigate the adverse effects of alcohol ingestion to the liver under the hepatobiliary disease. Serum AST Ⅰ-Ⅱ and AST Ⅲ-Ⅳ activities in CBD ligated rats combined with acute ethanol intoxication showed greater increases than that in CBD ligation alone. These results indicate that the leak of hepatic AST isozymes into blood is facilitated in CBD ligated rats combined with acute ethanol intoxication than in CBD ligation alone due to aggravated hepatic membrane damage. Liver mitochondrial AST Ⅰ-Ⅱ and AST Ⅲ-Ⅳ activities in CBD ligated rats combined with acute ethanol intoxication showed less increases than that in CBD ligation alone. However, liver microsomal UDP-GT activity in CBD ligated rats combined with acute ethanol intoxication showed a more decrease than that in CBD ligation alone. On the other hand, when acute ethanol intoxication was combined with CBD ligation, the values of Vmax of the liver mitochondrial AST Ⅰ-Ⅱ, AST Ⅲ-Ⅳ and liver microsomal UDP-GT decreased significantly than that in CBD ligation alone. However, the values of Km of above hepatic enzymes did not change. Viewed from these results, when acute ethanol intoxication was combined with cholestasis, these enzymes in the liver seem to be decreases their biosynthesis than that in cholestasis. According to all of the results, if ethanol intoxication is combined with cholestasis, the hepatic damage is aggravated.
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