http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
저알부민혈증을 보이는 혈액투석 환자에서 혈청 알부민에 대한 케토스테릴의 효과
오숙의 ( Sook Eui Oh ),이영기 ( Young Ki Lee ),김진경 ( Jin Kyung Kim ),이동훈 ( Dong Hun Lee ),김수진 ( Soo Jin Kim ),김성균 ( Sung Gyun Kim ),오지은 ( Ji Eun Oh ),서장원 ( Jang Won Seo ),윤종우 ( Jong Woo Yoon ),구자룡 ( Ja Ryon 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.1
Purpose: Malnutrition is a strong predictor of increased morbidity and mortality in patients on maintenance dialysis. Although a number of studies were performed to determine effective treatment, there is no proven medication for malnutrition. This study aimed to evaluate the effect of keto acids (ketosteril(R)) on serum albumin levels in hemodialysis patients with hypoalbuminemia. Methods: Hemodialysis patients with hypoalbumineia (serum albumin ≤3.8 g/dL) were enrolled. Exclusion criteria were previous supplementation of keto acids before the initiation of dialysis, acute infection, liver cirrhosis, malignancy and persistent hypercalcemia. Patients were treated with ketosteril for 6 months and serum albumin levels were compared to age- and gender-matched hemodialysis patients. Results: There were no significant differences in the baseline serum albumin levels between ketosteril group (n=19) and the control group (n=19). After 6 months, the mean (±SD) serum albumin level in the ketosteril group rose from 3.46±0.40 g/dL to 3.66±0.37 g/dL (p=0.01), but not the control group. However, the difference between the two groups was not significant (p=0.06). Multivariate analysis showed that the ketosteril supplementation (p=0.03) and the baseline serum albumin level (≤3.4 g/dL, p=0.04) were predictors of increased serum albumin. There was no severe hypercalcemia during the study period. Conclusion: There was an improvement of serum albumin levels in hemodialysis patients with hypoalbuminemia after the supplementation of keto acids.