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지유 (Sanguisorbae officinalis L.)의 항암 및 항균효과
안봉전 ( An Bong Jeon ),이순애 ( Lee Sun Ae ),손준호 ( Son Jun Ho ),곽재훈 ( Gwag Jae Hun ),박정미 ( Park Jeong Mi ),이진영 ( Lee Jin Yeong ) 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.1
The cytotoxic and antibacterial activities of Sanguisorbae officinalis L., which is blown as a major tannin source, were investigated to check the possible use of natural nutraceutics or cosmetics. The S. officinalis inhibited cancer cell growth in a dose-dependant manner. Also, the clear zone against various bacteria such as Staphylococcus aureus, S. epidermidis, E. coli were evident at 0.5 and 1 ㎎/dusc. When the concentrations were 500 and 1,000 ppm. growth of all aerobic bacteria increased at early stage but decrease afterward. The results indicated that S. officinalis had the anti-skin cancer activity as well as antibacterial activity against skin-related bacteria.
한국산 실거리나무 열매로부터 새로운 축합형탄닌 화학구조결정 및 고혈압 예방효과
안봉전 ( An Bong Jeon ),이진태 ( Lee Jin Tae ),박정미 ( Park Jeong Mi ),곽재훈 ( Gwag Jae Hun ),이진영 ( Lee Jin Yeong ),박찬익 ( Park Chan Ig ),손준호 ( Son Jun Ho ),임흥열 ( Im Heung Yeol ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objectives : The study was investigated decrease effiency for blood pressure of the pods of Caesalpinia sepiaria Methods : We isolated an novel compound as an angiotensin converting enzyrne(hrpertensive enzyme) inhibitor from the pods of Caedpinia sepiaria We measured inhibition rate of angiotensin converting enzyme. Results : We decided chemical structure of this new material, prodelphinidin B-3 3-0-gallate that combined with (+)-gallocatechin-3-O-gallate and (+)-gallocatechin by mechanical analysis. Effect of inhibition on the angiotensin converting enzyme was shown that B-ring, gallate compound in prodelphinidins, grown the effect of inhibition. Frodelphinidin B-3 3-0-gallate inhibited about 75.5% at 75 μmole, is shown a possibility that is used to industry. Conclusion : The pods of Chsalpinia sepiaria were expected functional agents for decreasing blood pressure at drug and food industry.
액정상을 이용한 O/W형 에멀젼의 제조 및 제형 안정화에 관한 연구
안봉전 ( An Bong Jeon ),이진태 ( Lee Jin Tae ),이인철 ( Lee In Cheol ),곽재훈 ( Gwag Jae Hun ),박정미 ( Park Jeong Mi ),박찬익 ( Park Chan Ig ) 한국유화학회 2004 한국응용과학기술학회지 Vol.21 No.1
N/A Liquid crystalline phases were formed from acylglutamate, polyglyceryl-10 myristate and glycerine mixture and they were used as a base material for preparing an O/W emulsion. When an oil phase is asses into the liquid crystalline phases, it was inserted into the dispersed liquid crystal droplets rather than stated outside the liquid crystals, which can be known by the fact that the size of liquid crystal droplets increases with the increasing oil phase content. Along with the increase in the droplet size, the complex modulus increases from 100 to 350 pascals and the loss angle decreases from 60 to 24 degrees, from which it can be known that increase in the internal phase volume results in the increase in the elastic property of oil in liquid crystalline phases (O/LC). When the water phase was lastly added into the O/LC phase, the emulsification occurred to form a O/W emulsion and the averaged particle size of the O/W emulsion chanres from 22.5nm to 538nm with the addition of water phase. The results from the droplet size measurements and stability tests under accelerated conditions such as high temperature show that the obtained O/W emulsion is very consistent with time.
안봉전 ( An Bong Jeon ),이진태 ( Lee Jin Tae ),곽재훈 ( Gwag Jae Hun ),박정미 ( Park Jeong Mi ),이진영 ( Lee Jin Yeong ),손준호 ( Son Jun Ho ),배종호 ( Bae Jong Ho ),최청 ( Choe Cheong ) 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.1
Biological activities and anticarcinogenicity of Korean Pear peel were investigated. Electron donating activity and superoxide dismutase (SOD)-like activity of fraction Ⅱ, Ⅲ were up to 80% and 50~60% at 50ppm, respectively. Inhibitory effects on xanthine oxidase were about 80% at 50ppm, breast adenocarcinoma was about 60% at 2,000ppm, higher Ⅲ than Ⅱ. Inhibitory effect on prostate adenocarcinoma was about 23% at 500ppm. In conclusion, Korean pear peel was expected to use as a functional material.
한국산 지유로부터 새로운 Glucosyltransferase 및 Tyrosinase Inhibitor 분리
안봉전 ( An Bong Jeon ),이진태 ( Lee Jin Tae ),박정미 ( Park Jeong Mi ),곽재훈 ( Gwag Jae Hun ),이진영 ( Lee Jin Yeong ),박찬익 ( Park Chan Ig ),손준호 ( Son Jun Ho ),임흥열 ( Im Heung Yeol ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objectives : The study was experimented anti-plaque and whitening efficiency of the roots of Sanquisorbae sfficinalis L. Methods : We identificated novel procyanidin structure established by thiolysis, desulfurization, tannase reaction, methylation and spectroscopic analysis, The physiological activity of anti-plaque and whitening efficiency was evaluated. Results : The chemical structure was identified for procyanidin B-3 3-0-gallate containing the dimeric flavan-&oh, gallate and molecular weight was 792[M-H]- by FAB-MS negative ion method. The inhibitory effect on the glucosyltransferase and tyrosinase activity was investigated, novel compound showed complete inhibition at 0.75mM on the glucosyltransferase and tyrosinase was inhibited about 50% at 1001.1M. Conclusion : The roots of Sanguisorbae @citmlis were expected functional agents for anti-plaque and whitening.