http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 고한철 · 박정평 · 박열 (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
-
녹농균의 항균제 내성양상 및 Rifampin과 Quinolone제와의 병합효과
박정평,고한철,나영천,임용,이현국,양남웅,박열 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Clinically isolated 92 strains of Pseudomonas aeruginosa were serotyped and their resistance patterns to total 24 kinds of antimicrobial agents (i.e., Penicillins, aminoglycosides, cephalosporins, quinolones) were studied by MIC(minimal inhibitory concentration). In addition, serotype G(16 strains) and E(16 strains), which isolated with high frequency in clinical field, were used for a study about combined effects of quinolones and rifampin by the checkerboard method. These drugs are being spotlighted as therapeutics of Pseudomonas aeruginosa infections. The results were as follows; Serotypable strains of Pseudomonas aeruginosa were 87 strains(94.6%) out of 92 strains clinically isolated. In these strains, G types were isolated in largest numbers(28 strains, 30.4%), E types were 25 strains (27.2%), B types 12 strains (13.0%), the other types were less than 7% and J,K,N types were not typed at all. In the MIC peak of each antibiotics, ciprofloxacin showed lowest peak as 0.25㎍/㎖, another third generation quinolones also showed low MIC peaks of 8㎍/㎖ and less. Amikacin, the aminoglycosides, and rifampin revealed MIC as low as 32㎍/㎖ relatively, but the others did not. MIC of gentamicin, tobramycin, nalidixic acid, rifampin, piperacillin and amikacin were distributed in a wide range of 0.5㎍/㎖ to >512㎍/㎖, but in MIC_(50) of all above antibiotics were 256㎍/㎖ or more, and MIC_(90) were above 512㎍/㎖, the third generation quinolones except rosoxacin showed very low MIC ranges less than 64㎍/㎖, and revealed good antimicrobial activities as seen in that MIC_(50) were less than 2㎍/㎖ and MIC_(90) were below 8㎍/㎖. On seeing MIC ranges according to serotypes, in most antibiotics, E types were slightly resistant than G types but there are no much differences. In combinations of rifampin and quinolones, rifampin-enoxacin combination revealed relatively as good synergistic effect as 37.5%(12 strains), rifampin-nalidixic acid showed 34.4%(11 strains), and the other combinations also showed good results comparatively. In addition, rifampin-ciprofloxacin had antagonistic effect of 31.3%(10 strains). But on the whole, it can be said that these combinations have much affirmative significance in antibiotic therapy to Pseudomonas aeruginosa. According to the serotypes, synergism of rifampin-nalidixic acid to G types was zero%(0 strain) and 31.3%(5 strains) to E types. All combinations except rifampin-nalidixic acid revealed high synergistic effects to E types and in proportion to this, antagonistic effects were low. This high synergistic effects to E types were in a contrast to slightly high resistance patterns of E types.
-
Pseudomonas aeruginosa의 항생제내성에 관하여
高漢喆,朴政枰,朴悅 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.1
In order to study the MIC distribution and serotypes of p. aerugmosa, 112 strains isolated from two general hospital in kwangju city were tester). The following results were obtained. 1. Among 112 strains of p. aeruginosa isolated, 107 strains(95.5%) were typable. serotype E(30.4%) and G(30.4%) were most prevalent followed by B(11.6%), serotype A(7.1%) and serotype F, I(1.8%) among 107 typable strains. 2. According to test of MIC distribution on 17 antibiotics against p. aeruginosa. aminoglycosides were 0. 5~>512mcg/㎖, MIC peak in AK 32mcg/㎖ and other antimicrobial agents were > 512mcg/㎖. penicillins were 4~>512mcg/㎖, MIC peak in pi 256mcg/㎖ and other antimicrobial agents were >512mcg/㎖. Cephalosporines were 8~>512mcg/㎖, MIC peak in CP 64mcg/㎖ and other antimicrobial agents were>512mcg/㎖. 3. Among those antimicrobial agents, amikacin and rifampin showed good antimicrobial activity. 4. All of drug-resistant p. aeruginosa strains were multiply resistant to nine or more drugs. 35 strains were resistant to 17 drugs, follwed by 21 strains resistant to 15 drugs, 9 strains resistant to 14 drugs. 5. Out of 9~17 drugs, E. and G serotypes were 34 strains, out of 9~17 drugs, B sero-type were 13 strains, out of 13~]7 drugs, A serotype were 8 strains.
-
녹농균의 quinolone제재에 대한 감수성 및 혈청형 분포
최승호,고한철,이현국,박정평,임용,양남웅,김학렬,박열 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
123 strains of Pseudomonas aeruginosa isolated from various clinical specimens were tested for the distrution of serotypes and the evaluation of the antimicrobial susceptibility to each generation quinolone impounds. The results were as follows : 1. 107 strains(87%) were typable out of clinical isolate 123 strains. Serotype G was prevalent with 33 strains (26.8%) and followed by serotype E, 31 strains (25.2%), serotype B, 15 strains (12.2%) and successively typed in the order of serotype A, C, D, F, H, I, L, M, but serotype J,K and N were not entirely typed. 2. MIC peak was 1024ug/ml in case of nalidixic acid, 32ug/ml in pipemidic acid, 0.25ug/ml in ciprofloxacin, 2ug / ml in ofloxacin. 2ug/ml in enoxacin. 0.5ug/ml in norfloxacin, finally 8ug/ml in rosoxacin. 3. The second generation quinolone compound, pipemidic acid exhibited 8 to 30 times higher activity to Pseudomonas aeruyrtcisa than the first generation quinlolne, nalidixic acid. And the third generation compounds showed 4 to 100 times higher activities than the second generation quinolone. Especially ciprofloxacin showed 2 to 30 times higher antimicrobial activity than other generation quinolone compounds. 4. There were no significant differences to susceptibility patterns among the serotypes.
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
