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Quantitative Analysis on Cellular Uptake of Clustered Ferrite Magnetic Nanoparticles
김유진,Bum Chul Park,Young Soo Choi,고민준,Young Keun Kim 대한금속·재료학회 2019 ELECTRONIC MATERIALS LETTERS Vol.15 No.4
Due to their ability to be internalized into cells by endocytosis through cell membranes, the application of nanoparticlesin therapeutic and diagnostic fields has received much interest. In particular, ferrite magnetic nanoparticles (MNPs) arewidely used as reagents for medical care, including in vitro magnetic separation, T2-weighted magnetic resonance imaging,magnetic hyperthermia therapy, and as drug delivery systems. However, little is known about the quantitative analysis ofthe cellular uptake of MNPs by the interaction of particle surfaces with biomolecules. Here, we quantitatively analyze theintracellular uptakes of 30 nm Fe- and Mn-ferrite MNPs. We confirm that the magnetic properties of MNPs change accordingto their microstructure and quantitatively analyze nanoparticle internalization in breast cell lines (MCF10A, MCF7, andMDA-MB-231) by measuring the magnetic moment using a vibrating sample magnetometer. Finally, we examine the effectof nanoparticle microstructure on cellular uptake in terms of the interaction between the nanoparticles and biomolecules.