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RISS 인기검색어
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- 저자 : 강창기(Chang-Gee Kang) (검색결과 3 건)
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김현옥,강창기,정윤섭,이삼열 대한감염학회 1985 감염 Vol.17 No.1
Blood culture is a very important procedure in the diagnostic bacteriology to determine the etiologic agent, and the antimicrobial susceptibility test is also and essential part of the work to guide the therapy. It has been known that both the bacterial species isolated from blood and their antimicrobial susceptibility may change their patterns as time goes. In this study an analysis is made on the results of both blood cultures and the susceptibility of the isolates done at Yonsei Medical Center during 1974 to 1983. The following results were obtained. A total of 78,732 blood specimens were cultured and 12,963 positive results (8,012 patients) were obtained. During this period of time, the number of positive patients per 1,000 admissions increased from 15.3 in 1974 to 24.7 in 1983. Among the isolates, 96.4% were aerobic or facultative bacteria, 2.7% anaerobes and 0.9% fungi. The most commonly isolated pathogens were S. aureus, α-hemolytic Streptococcus, S. typhi, E. coli and P.aeruginosa. The proportion of S. typhi to total positive cultures decreased from 52% in 1974 to 19% in 1983, while the proportion of other species of Enterobacteriaceae increased. Species of Enterobacteriaceae were frequently isolated from both pediatric and senile patients. S. typhi was most frequently isolated from the age group of 20-49 years. Seasonal isolation rate of S. typhi showed two peaks, one in June-July and the other in December-January. Most of the other bacteria were somewhat more frequently isolated during summer months. Polymicrobial bacteremia were found in 4.2% of patients with positive blood cultures. Most of the organism involved were E. coli, K.pneumoniae, P. aeruginosa and S. aureus. An increase of antimicrobial resistant strains of S. aureus, Enterobacteriaceae with the exception of S. typhi, and P. aeruginosa were noted during the study period. Many of the currently isolated strain of S. aureus, Enterobacteriaceae and glucose non-fermenting gram-negative bacilli were resistant to commonly used antimicrobial agents. It is concluded from this study that S. aureus remains to be a frequently isolated pathogen, the proportion of S. typhi has been decreasing, the bacteremia due to gram-negative bacilli has been increasing, V. vulnificus is an important new pathogen recognized during this period and the increase of resistant strains of bacteria poses problem in the selection of therapeutic agents.
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