韓國 精神障碍의 疫學的 調查硏究(V]|[) -巩不安障碍-

李定均,卞永贊 대한신경정신의학회 1987 신경정신의학 Vol.26 No.1

In order to study generalized anxiety disorder, this epidemiological survey was perform ed, using D IS -III (Diagnostic Interview Schedule, version III) Korean version by lay interview ers. Subjects w ere selected according to m ultistage cluster sampling mothod together w ith simple ramdom sampling and 2,865 respondents in Seoul and 1,439 in overall rural area completed the study. The results w ere as follow s : 1) The lifetim e prevalence rate was 3.40% . 2) The lifetim e prevalence rate was nearly triplicated by point prevalence rate. 3) There was a tendency that prevalence rate became increased along w ith age and tim e period. 4) As fo r sex, prevalence rate was significantly higher in women than in men. 5) the mean age of onset o f symptoms was 32.4 years. 6) The mean duration o f symptoms was 74.1 weeks.

非定型精神分裂症의 症狀 및 鑑別診斷

李定均 대한신경정신의학회 1978 신경정신의학 Vol.17 No.3

韓國人의 MMPI에 關한 硏究 第5 編 : 精管手術者의 MMPI

李定均 대한신경정신의학회 1966 신경정신의학 Vol.5 No.1

Studies on the standardized (revised) MMPI for Koreans were conducted on the vasectomy cases who have had problems after vasectomy and ccrcpared with normal cases. The following conclusions were obtained. 1. The differences between the vasectomy group and normal group in validity scales are as follows: a. No significant difference in the scale, b. The F scale is much higher in the vasectomy group than the normals. c. The K scale is higher in the normals thait the vasectomy group. 2. Score of the vasectomy group is higher than the normals in the all clinical scales, except Mf scale. 3. The vasectomy group tend to present exaggeratetheir own deficiencies, also have a tendency to be overly honest or self-criticism. 4. The Si scale is the highest score and also Hs.,D Pt. and H y ., showed high score in the clinical scales. The lowest score are Pd. and Ma. scales. 5. The vasectomy group showed depressed, tense, indecisive, unhappy, worries a great deal, introverted, anxiety, obsessive-compulsive tendency, marked loss of initiativeness and efficiency, and generally dependent compared with the normals. 6. An Anxiety Index and An Internalization Ratio are both higher in the vasectomy group than normals that means the vasectomy group have more anxiety and also have a tendency to internlize their difficulties under the stress rather than act out compared with normals. 7. We have to consider that psychiatric study(including personality test) should be done before the vasestomy, so could avoid neurotic person who might have problems after vasectomy.

韓國 精神障碍의 疫學的 調査 研究 (15) ᅳ알코올리즘의 有病率ᅳ

李定均,李査恒 대한신경정신의학회 1994 신경정신의학 Vol.33 No.4

The nationwide epidemiological study of mental disorders including alcoholism in Korea using DIS-III Korean version was conducted in the Capital City of Korea (Seoul) and 20 rural areas and compared to the other 10 countries. The results were a follows: 1) The lifetime prevalence alcoholism was 21.98%, Seoul was 21.73% and rural areas was 22.39%. 2) As for sex, male was for more prevalent than female, male was 45.56% and female was 2.23%. 3) The most prevalent age group was 28.55 % in 45_65yrs. old group. 4) Mean age of alcoholism was 29 years old, Seoul area was 28 years old(male 28 years old, female 34 years old) and rural areas was 30 years old(m ale 30 years old, female 38 years old). 5) mean number of positive alcohol symptoms was 5.5, Seoul was 5(male 5, female 4) and rural areas was 6(male 6,female 4.5). 6) Symptom profile of alcoholics among nonalcoholics, abuse only and dependence were compared. The most prevalent symptom of pattern of pathological alcohol use was dependence group, abuse and nonalcoholics in order. The tendency was seen in impairment of social or occupational function and tolerance or withdrawal. ᄀ) Phobia disorders, cognitive impairment and depression were prevalent in order in comorbidity aomong nonalcoholics and alcoholics. Also, comorlidity was higher in alcoholics compared to nonalcoholics. 8) Comparison among 7 countries(Korea, USA, Puerto Rico, Canada, Germany, New Zealand and Taiwan) were as follows: (1) The highest lifetime prevalence of alcoholism was 21.98% in Korea and New Zealand, Canada, USA, Germany, Puerto Rico and Taiwan in order. (2) Mean age of onset, the latest was 32.7 years old in Germany and the earliest was 18 years old in New Zealand. (3) Male had higher prevalence rate in all countries. (4) Comparison of age group, 25 ᅳ 44 years old group had the highest prevalence rate except Korea was 45 ᅳ 65 years old group.

韓國 精神障碍의 疫學的 調査 研究(XIII) ᅳ 強迫障碍의 有病率 ᅳ

李定均 대한신경정신의학회 1994 신경정신의학 Vol.33 No.1

A nationwide epidemiological study of mental disorders including obsessive-compulsive disorder in Korea using DIS-III Korean version was conducted in the Capital City o f Korea (Seoul) and 20 rural areas and the results were compared with those o f 6 other countries. The results were as follows : 1) The lifetime prevalence rate of obsessive-compulsive disorder was 2.14%, 2.299% in seoul and 1.90% in rural areas. 2) As for sex, the lifetime prevalence rate was higher in females, than in males, 2.03% in male and 2.38% in female. 3) The most prevalent age group was 18—24 yrs. old group(2.45%). 4) The lifetime prevalence rates of OCD of seven countries (Korea, USA, Canada, Puero Rico, New Zealand, Germany and Taiwan) were remarkably consistent across the cross-national sites. Most of the sites fall within the range of 1.9% (Korea) to 2.5% (Puerto Rico). The annual rate of OCD was also fairly consistent across sites, ranging from 1.8 (Puerto Rico) to 1.1 % (Korea and New Zealand). 5) Mean age of onset of OCD was in the mid-to late twenties to early thirties, with the earliest mean age at Canada(21.9yrs) and the latest at Puerto Rico(35.5 years). 6) The lifetime rate by sex, was generally higher in females as compared to males, except for Germany where males had a higher rate than females. In New Zealand, females had the highest rate among all of the females(3.4%) and in Germany males had the highest rate among all of the males(2.5%), The female to male ratios were consistent for Korea(1.2), Puerto Rico(1.2), Canada(1.3),USA(1.6) and Taiwan(1.8). 7) Proportion of persons with only obsession, only compulsion and both were also compared. In USA, Canada, Puerto Rico and New Zealand there was a larger proportion of persons with only obsession as compared to only compulsion. In Germany and Taiwan the proportion were equal and in Kroea there was a higher proportion of persons with compulsion only, just the opposite trend seen in most of the other sites. 8) Germany had the highest proportion of persons with both obsessions and compulsions. Most of th countries fall within the 13% to 26% range, with Puerto Rico slightly higher. 9) Comorbidity with major depression and any anxiety disorders (panic disorder or any phobia) in persons with and without OCD for the cross-national sites were compared. Persons with OCD were at a risk substantially greater than chance of also having comorbid major depression or any anxiety disorders as compared to persons without OCD across all sites, even though the comorbidity rates and the magnitude of risk vary by sites. The proportion of persons with OCD and any anxiety disorder were higher than that proportion with major depression. Persons with OCD at Munich (Germany) seemed to have higher proportion with major depression and anxiety disorder and are at greater risk than persons without OCD compared to the other sites.

韓國 精神障碍의 疫學的 調查 研究(XIV ) - 兩極性 障碍 및 主要憂戀病의 有病率 一

李定均 대한신경정신의학회 1994 신경정신의학 Vol.33 No.1

A nationwide epidemiological study of mental disorders including bipolar disorder and major depression in Korea using DIS-III Korean version was conducted in the Capital City o f Korea (Seoul) and 20 rural areas and the results were compared with those o f 9 other countries. The results were as follows : 1) The lifetime prevalence rate of obsessive-compulsive disorder was 0.42%, 0.40% in seoul and 0.44% in rural areas. The lifetime prevalence rate of major depression was 3.37% (3.31 % in Seoul and 3.47% in rural areas). 2) As for sex, the lifetime prevalence rates or bipolar disorder were 0.65^ in male and 0.20% in female, and those of major depression were 2.61 % in male and 4.06% in female. 3) The most prevalent age group of bipolar disorder was 18〜 24 years old group and was 45〜65 years old group in major depression. 4) The lifetime prevalence rates of bipolar disorder were compared between 10 countries (K orea, USA, Canada, Puerto Rico,France, Germany, Italy, Lebanon, Taiwan, New Zealand). It was lowest in Korea, Germany and Taiwan(0.4%) and highest in New Zealand(1.4%). The earliest mean age of onset was shown in USA, 18.1 yrs. old, and the latest in Puerto Rito, 29.2yrs, old. 5) Also the lifetime prevalence rates of major depression were compared between 10 countries. The lowest was 1.5% in Taiwan, and the highest was 19.0% in Lebanon. The lowest annual prevalence rate was 0.8% in Taiwan and the highest was 6.3% in Germany. The ealiest mean age of onset was 24.8 yrs. old in Cahada and the latest was 34.8 yrs. old in Italy. 6) As for sex, in bipolar disorder, the prevalence rate among the males were lowest in Germany (0.0%) and highest in New Zeafound(l.7%). Those among the females were lowest in Korea(0.2%) and highest in New Zealand(1.2%). 7) In major depression, the prevalence rate among the males were lowest in TaiwanCl.l and highest in Lebanon(l4.7%). Those among the females were lowest in Taiwan(l.8%), and highest in Italy(l8.1%). 8 ) Symptom occuring in 50% or more persons with major depression were as follows: (1) poor appetite—Korea,Canada, Puerto Rico, France, Lebanon, Taiwan. (2) weight loss—Lebanon. (3) insomnia and loss of energy-all countries. (4) retardation, agitation and decreased in sex-Lebanon. (5) worthless, guilt and concentration-all countries (6) slowed thinking-Korea, Canada, Lebanon, Taiwan, New Zealand. (7) thought of death —all countries except Germany, Taiwan. 9) Symptom occuring in 60% or more persons with major depression were as follows (1) poor appetite-Korea, Lebanon, Taiwan. (2) insomnia and loss of energy—all countries. (3) decreased sex—Lebanon. (4) worthless, guilt—all countries except Puerto Rico, Lebanon, Taiwan. (5) concentration—all countries except Korea and Germany. (6) slowed thinking—Korea, Canada, Lebanon, Taiwan. (7) thought of death-USA, Canada, Puerto Rico, Lebanon, New Zealand.

不眠에 對한 8ᅳChloro-6-Phenyl-4H-s-Triazolo〔4.3ᅳa〕 〔1.4〕 Benzodiazepine 의 効果에 關한 臨床硏究

李定均,榻秉換 대한신경정신의학회 1976 신경정신의학 Vol.15 No.4

In this studyi authors Examined the hypnotizing effect of Estazolam on patients in I. P. D & 0. P.D. who visited with the chief complaint of insomnia The number of patients selected for this study were 156. They were consisted of 78 neurotics other than depression, 66 depressive patients and 12 mild psychotic patients. Authors applied the double blind clinical method with Estazolam and placebo to the patients. They visited OPD & IPD of Psychiatric department of SNUH (Seoul National University Hospital) from October-1, 1975 to March-31, 1976. The results were as follows: 1. Estazolam had the highest sedating effect to the patients with mild psychosis and the least effect to the neurotics except depression. 2. Total duration of sleep increased approximately 20-30 minutes. 3. No difference was noticed between 2mg and 3mg administrated groups. 4. It seemed that Estazolam had no influencoe on REM sleep pattern (frequency of dream). 5. It was a most effective method to use Estazolam combined with other specific drugs to the patient who had suffered from insemnia for a long period.

韓國 精神障碍의 疫學的 調查 硏究(M) -恐慌 障많와 國家別 比較-

李定均,李査恒 대한신경정신의학회 1995 신경정신의학 Vol.34 No.6

The nationwide epidemiological study of mental disorders including panic disorder in Korea using DSM-III Korean Version was conducted in the Capital City of Korea(Seoul) and 20 rural areas and compared to the other 9 countries. The results were as follows ; 1. The life time prevalence o f panic disorder o f Korea was 1.68%(Seoul 1.11% and rural areas 2.60%). 2. As for sex in Korea, female was for more prevalent than male, female was 2.9% and male was 0.5%. 3. The most prevalent age group in Korea was 2.6% in 46 - 64 years old group. 4. Mean onset age of panic disorder in Korea was 31.7 years old. 5. One m onth prevalence rate in Korea was 1.2%(female 2.1%, male 0.3%), six months prevalence rate was 1.4%(female 2.2%, male 0.4%) and anual prevalence rate was 1.5%. 6. Symptom profile o f life time panic disorder o f Korea were palpitation(93.7%), dyspnia and chocking or smothering sensation(both 81.0%), dizziness or verrigo(80.0%),chest pain or discomfort(76.8%) and trembling or shaking(71.6%). 7. Com obidity o f lifetime psychiatric disorders with panic disorder o f Korea were any phobia 45.3%(simple phobia 38.9%, agoraphobia 34.7% and social phobia 10.5%), major depression 28. 4%, dysthymia 16.8%, obsessive compulsive disorder 13.7%, alcohol abuse 13.7% and drug abuse 7.4%. 8. Unadjusted lifetime prevalence rate o f suicide attempts o f Korea in person with panic d isorder was 17.6% and without panic disorder was 2.8%. 9. Comparison among 10 countries(Korea, USA, Canada, Puerto Rico, France, Germany, Italy, Lebanon, Taiwan and New Zealand) were as follows ; 1) The highest lifetime prevalence was Germany(3.2%) and Italy, France, Lebanon, New Zealand, USA, Puerto Rico, Korean, Canada and Taiwan in order. The highest female and male ratio was Korea(5.9) and the lowest was Puerto Rico(1.3). 2) The highest one month prevalence was Lebanon(1.4%) and the lowest was New Zealand (0.4%). The highest female male ratio was Korea(7.0) and the lowest was Puerto Rico(0.7). 3) The highest six months prevalence was Lcbanon(2.1%) and the lowest was USA. The highest female male ratio was Korea(5.5) and the lowest was Puerto Rico(0.7). 4) The earliest mean age of onset was New Zealand(23.2) and the latest was Germany(33.3). 5) Comparison of symptom profile of lifetime panic disorder were as follows ; (1) The highest symptom profile of dyspnea was Puerto Rico(84.6%), palpitation was Korea (93.7%) chest pain or discomfort was France(79.5%), chocking or smothering sensation was Korea(81.0%), dizziness and vertigo was Korea(80.0%), feeling of unreality was Puerto Rico(76. 9%), paresthesia was Puerto Rico(57.7%), hot and cold flushes was New Zealand(80.4%), sweat ing was Canada(87.0%), faintness was Korea(68.4%), trembling or shaking was Canada(89.1%) and fear of dying, going crazy was Puerto Rico(80.8%). (2) The lowest symptom profile of dyspnea was New Zealand(52.2%), palpitation was Lebanon( 40.0%), chest pain or discomfort was USA(50.8%),choking or smothering sensation was USA(43.2%), dizziness and vertigo was Lcbanon(40.0%), feeling of unreality was Korea(40.0%), paresthesia was New Zealand(17.4%), hot and cold flushes were Taiwan(37.5%), sweating was Lcbanon(20.0%), faintness was Canada(43.5%), trembling and shaking was Lebanon(20.0%) and fear of dying, going crazy was Taiwan(50.0%). 6) Comparison of comorbidity of lifetime psychiatric disorders with panic disorder were as follows ; (1) The highest prevalence with major depression was Canada(65.2%), dysthymia was Canada (32.6%), bipolar disorder was Puerto Rico(19.2%), phobia was Puerto Rico(76.9%), obsessive compulsive disorder was New Zealand(19.6%), alcohol abuse was Canada(47.8%), drug abuse was Canada(39.1%),schizophrenic disorder was Puerto Rico(30.8%),somatization disorder was Puerto Rico(15.4%) and antisocial personality disorder was USA(9.0%). (2) The lowest prevalance with major depression was Taiwan(22.5%), dysthymia

韓國 精神障碍의 疫學的 調査 硏究(XVII)

李定均,李査恒 대한신경정신의학회 1996 신경정신의학 Vol.35 No.5

The nationwide epidemiological study of mental disorders including major depression and bipolar disorder in Korea using DSM-III Korean Version was conducted in the Capital City of Korea(Seoul) and 20 rural areas and compared to the other 9 countries. The results were as follows : 1) The lifetime prevalence of major depression of Korea was 2.9%(female 3.8%, male 1.9%), female/male ratio was 2.0 and mean age o f onset was 29.3 years old. 2) The most prevalent country of lifetime prevalence of major depression were Lebanon and France and lower were Taiwan and Korea. In females higher were Lebanon and France and lower were Taiwan and Korea. In males, the highest was Lebanon and lower were Taiwan and Korea. The higher were West Germany and Italy and lower were Lebanon and Taiwan in the female/male ratio. In mean age of onset, younger were Canada 24.8, Lebanon 25.2 and USA 25.6 and Italy 34.8 was the oldest. 3) The most prevalent country o f bipolar disorder were New Zealand and USA and lower were Taiwan and Korea. In females, higher were New Zealand, USA and West Germany and the lowest was Korea. The highest was New Zealand and the lowest was Taiwan in males. The highest female/male ratio was USA 1.2 and the lowest was Korea 0.3. The oldest mean age of onset was West Germany 29.0 and the youngest was Canada 17.1. 4) Comorbidity (1) Alcohol abuse/dependence : ① Comorbidity of alcohol abuse/dependence was higher in Korea and Canada and the lowest was in Taiwan. ② Alcohal abuse/dependence without M D D was highest in Korea and the lowest was in Taiwan. (2) D rug abuse/dependence : ① Comorbidity of drug abuse/dependence was highest in USA and the lowest was in Taiwan. ② Durg abuse/dependence without MDD was highest in USA and the lowest was in Taiwan. (3) Panic disorder : ① Comorbidity of panic disorder was highest in Korea and the lowest was in Taiwan ② Panic disorder without MDD was highest in New Zealand and lowest was in Taiwan (4) Obsessive compulsive disorder : ① Comorbidity of Obsessive compulsive disorder was highest in West Germany and the lowest was in Taiwan. ② Obsessive compulsive disorder without MDD was highest in Canada and Puerto Rico and the lowest was in Taiwan. 5) Marital status in major depression were : (1) The highest in separation/divorce was USA and the lowest were Lebanon and Korea. (2) The highest in being married were West Germany and France and the lowest was USA. 6) Symptom occurring in 60% or more population with major depression were : (1) poor appetite - Lebanon, Taiwan and Korea (2 ) insomnia and loss of energy - all countries (3) agitation - Lebanon (4) worthless and guilt - all countries except Puerto Rico and Taiwan (5) concentration difficulty - all countries except Korea (6 ) slowed thinking - Canada, Lebanon, Taiwan and Korea (7) thought of death — all countries except France, Taiwan and Korea

韓國에 있어서의 精神障碍 - 曰本에서의 辑演 -

李定均 대한신경정신의학회 1972 신경정신의학 Vol.11 No.3