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박선규,조형상 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.4
In the treatment of metabolic acidosis, sodium bicarbonate(NaHCO_3) is used frequently and the dose is usually calculated on the assumption that the administered bicarbonate distributes in a space ,equivalent to 30~50% of body weight. In a case of profound metabolic acidosis, the apparent space of distribution of bicarbonate can be markedly increased and influenced by the pre-existing plasma bicarbonate concentration. This theory was tested with a usual dose of bicarbonate (1.5 mmoles/kg of body weight) every 20 minutes in 10 dogs that had been made acidotic(ph 7.1 level) by intravenous administration of 0.6-N HCl. In addition to this, the pH and Pco_2 in cerebrospinal fluid(CSF) and arterial blood, serum potassium level, mean arterial pressure(MAP) and heart rate were measured throughout the experiment. The pH and Pco_2, of the CSF were normal or near it. MAP was significantly reduced but the heart rate did not show any significant change. There was an increase in serum potassium concentration during metabolic acidosis but it gradually decreased to normal levels as NaHCO_3 corrected this acidosis. The apparent space of distribution of bicarbonate was over 150% of the real body weight in severe metabolic acidosis(pH 7.116~7.138). These results indicate that the administration of NaHCO_3 corrected the acidosis and normalized the serum potassium level & MAP; but had little effect on CSF parameters & heart rate. Also the results suggest that in some conditions of profound metabolic acidosis commonly recomrnended amounts of bicarbonate may produce unexpectedly small increments in the plasma concentration.
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박선규,이범식,한만엽 한국전산구조공학회 1998 전산구조공학 Vol.11 No.4
PSC 연속 평판슬래브의 설계는 부정정 평판슬래브에 대한 정확한 해석의 어려움 등으로 등가보이론과 등가골조이론에 의한 근사식을 수정없이 사용하거나 컴퓨터를 이용한 해석에 의존하고 있으나 해석결과를 간단하게 정확히 평가할 수 있는 기법은 없는 실정이다. 또한 PSC 연속 평판슬래브의 부재력은 긴장재의 곡선형태에 따라 변하므로 실제 설계시 PS 긴장재의 정확한 곡선식을 찾는 것은 매우 중요하다. 본 연구에서는 비부착 PSC 연속 평판슬래브를 설계할 때 기둥과 기둥을 연결하는 PS 긴장재의 기하학적 곡선형태를 결정하는 방법과, PS 긴장력으로 인해 발생하는 평판슬래브의 기둥부 휨모멘트에 대하여 판이론을 기초로 간편하게 계산하는 방법을 제안하였다. 본 연구에서 제안된 이론으로 계산된 PSC 연속 평판슬래브에 대한 해석값과 유한요소 해석에 의한 지점 부모멘트를 비교 검토하여, 본 논문에서 제시한 기법의 타당성을 입증하였다. 따라서 본 연구는 설계자에게 컴퓨터의 해석결과를 간단하고 정확하게 검증할 수 있도록 하였다.
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朴善圭 우석대학교 의과대학 1967 우석의대잡지 Vol.4 No.2
In surgical cases infected outside of hospital, staphylococcal strains were isolated simultaneously from lesion and nasal cavity of the sate individual. 128 of respective strains, reaching a total of 256 were studied on several biological properties and the relationships of strains between the two groups. 1. Strains from infected lesion (L.S.) showed higher ability of coagulase producton than strains from nasal cavity of the same individual (N.S.) (78.8% : 60.9%). 2. Regardless of their isolation locality, coagulase positive strains fermented mannitol markedly more than coagulase negative strains (92.5% : 32.9%), and L.S. showed higher reaction of mannitol fermentation than N.S. regardless of coagulase production. Therefore it is assumed that the ability of mannitol-fermetation showed a close relationship between coagulase production and pathogenicity. 3. Regardless of the isolation locality, coagulase positive strains showed much higher β-hemolytic toxin productivity than negative strains (86.0% : 31.7% ), and L.S. showed greater β-hemolytic toxin production than N.S. regardless of coagulase production, It is obvious that a close correlation exists among β-hemolrtic toxin, coagulase and pathogenicity. 4. In coagulase positive strains, PC resistants of L.S. and N.S. were 85.7% and 76.7% respectively ; SM resistants were 48.9% and 53.3% ; OT resistants were 50.5% and 45.5%. 5. 86.0% of L.S. was phage typable and its distribution of type were Group Ⅱ (44.2%), 80/81 (18.6%), 80/81+(16.3%), Miscellaneous group (4.7%), Group Ⅲ (2.3%) in order, while 84.6% of N.S. was phage typable and its distributions of type were Group Ⅱ (35.9%), Group Ⅲ (18.0%), 80/81+(16.7% ), 80/81 (7.7% )Miscellaneous group (3.8%). Group Ⅰ (2.7%) in order. 6. Miscellaneous group and Group Ⅱ phage type were most predominant in skin infection and abscess: its phage patterns were 3A/3C, 3B/3C/55/77, and 80/81+ in skin infection, and 55/71 and 80/81+ were in abscess. 7. Both sources of strains of L.S. and N.S. in the same individual rhowed relatively high coincidence rate in the ability of coagulase production (55.1%), the fermentation of mannitol (85.7%), the production of β hemolysin (79.2%), and in the sensitivity to PC (54.1%), SM (56.3%), OT (55.5%), and in the phage type 50.7%). 8. A close correlation between L.S. and N.S. of the same individual is observed from the high coincidence rate shown above.
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무호흡상태의 개에서 기관지내 지속적인 공기주입이 심폐기계에 미치는 영향
박선규,김석주,라은길,김진윤 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.4
Background : Mass casualties from organophosphrous inhalation die from respiratory depression. Gas supplies and equipment are limited for mechanical ventilation of multiple subjects. Endobronchial insufflation of air (EIA) requires only a compresssor and airway catheters. We examined clinical usefulness of EIA in a model of apnea produced by tetrodotoxin (TTX) infusion. Methods : Five anesthetized dogs were applied the conventional mechanical ventilation (CMV) while 12 mcg/kg TTX was infused IV over 90 min to produce apnea. EIA at 1 L/kg/min was delivered through a 35 cm long 0.8 cm I.D. catheter with a forked end placed astride the carina. Measurements of cardiovascular and respiratory function were made after TTX (time=0) on CMV, and then serially for 4 hours of EIA. Results: All dogs survived through 4 hours study. PaO2 decreased significantly within 30 min and then slowly increased significantly after 60 min. PaCO2 increased significantly within 30 min and decreased significantly after 60 min. HR increased significantly after 20 min and MAP increased significantly after 60 min. Mean SD of PaO2, PaCO2, pHa, SaO2, cardiac output, mean pulmonary pressure, mean arterial pressure, systemic vascular resistance, central venous pressure and Qs/Qt are shown in table. Spontaneous respiratory efforts slowly returned after 45 min of EIA and resulted in the improvement of gas exchange. Conclusion : EIA is a field ventilatory technique useful when other equipment may not be available. The airway catheter can be placed by cricothyroidotomy. EIA supports life and produces normal survivors in apneic dogs. (Korean J Anesthesiol 1998; 35: 599∼606)
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