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崔致敎,柳虎烈 경북대학교 의학연구소 1969 慶北醫大誌 Vol.10 No.1
Colorimetric method for hippuric acid (Umberger, D. J. and Fiorese, F. F. : Clinical Chem., 9:91,1963) was applied for the determination of urinary hippuric acid and led to a test applicable for the quantitative estimation. Urinary hippuric acid, determined by the colorimetric method, was found to be about 60∼70% of administered sodium benzoate. In attempts to separate urinary C^14-compounds by thin layerchromatography after administration of sodium benzoate-C^14 (300 μmoles/100g body wt.) two major fractons, hippuric acid-C^14, and benzoic acid-C^14 were identified. The total urinary C^14 was about 90% of test dose and the ratio of hippuirc acid-C^14 to benzoic acid-C^14 was about 3 : 1. The ratio was significantly reduced with increased excretion of free benzoic acid in fasting rats. Discussion was made on the advantage of the ratio determination as a more valuable criterion of benzoic acid detoxication than determination of urinary hippuric acid alone in rats.
張泰守,朴鍾吉,崔致敎 경북대학교 의학연구소 1964 慶北醫大誌 Vol.5 No.1
Ascariasis is still a world-wide disease in spite of its intensive erradication campaigns in certain parts of the world. With experiences of five cases of such biliary ascariasis during the last three years, the authors made clinical observation with a brief review of the literature. The age ranged from five years to sixty three years old; three cases were under thirty year old. As for sex, one case was male and the other four cases were females. Two cases of them were associated with cholelithiasis (40%), whereas three patients developed gross jaundice. All cases were misdiagnosed precperatively; three cases as cholecystitis with cholelithiasis, one as acute cholecystitis, and still another as obstructive jaundice due to retained gallstone following cholecystectomy. Though ascaris ova were positive in all cases, no significant importance could be attached to the positive stool test in these epidemic areas. Laboratory findings varied in each case of them. Consequently, it seems wise to think of the possibility of biliary ascariasis when encountered with unusual bizarre cases of biliary tract disease. Cholecystectomy was performed in all cases along with exploration of common bile duct. All cases made an uneventful postoperative course.