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- 저자 : 姜福秀 (검색결과 135 건)
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Caffeine 및 EDTA가 赤血球의 渗透的 脆弱性에 미치는 影響
姜福秀,李尙鴻,李文杰,呂雄淵 최신의학사 1968 最新醫學 Vol.11 No.10
Caffeine, ethylene diamine tetra acetic. acid (EDTA) or sodium fluoride (NaF) was added in vitro to the blood sampled from normal dog. The concentration of each drug used was NaF; 0.025 M., caffeine; 0.017 M., and EDTA 0.025 M., and osmotic pressure was adjusted by addition of dextrose in appropriate amount. Each drug solution in amount of 16.5 ml was added to the blood sample of 100 ml and osmotic fragility was measured in 0.45% 0.50%, and 0.55% saline solution respectively, at first, second and fourth hour` after the administration of drug to the blood. For the measurement of osmotic fragility, one part of drug treated blood sample was mixed into 100 parts of.each saline solution and the amount of hemoglobin released from hemolyzed red cell was determined by means of photometric analysis. Results obtained were analysed and compared with that of the control in which isotonic dextrose solution was added to the blood and all other experimental conditions given were same as those of drug treated blood. Sodium fluoride increased red cell osmotic fragility significantly and the increase in fragility of EDTA. treated red. cells was more remarkable than that of NaF treated red cells, whereas caffeine showed no significant effect on red cell osmotic fragility. In control and NaF treated blood, osmotic fragility tended to increase as the time progressed, on the other hand, osmotic fragility showed a tendency to decrease as the time "progressed in caffeine or EDTA treated blood, at 0.-55% saline solution particularly. Loss of the lipopolysaccharide from cell wall layer23) and increase in permeability of cell membrane24) as an effect of EDTA on the membrane seemed to be responsible for the cause of increase in red cell fragility in _ EDTA treated blood. And as the caffeine has inhibitory effect on 3, 5'-phosphodiesterase26) inducing accumulation of 3', 5'-AMP, authors were impressed _that caffeine may decrease red cell osmotic fragility enhancing the rate of glycolytic and some other metabolic processes.
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강복수,김석범,이경수,윤성호,Kang, Pock-Soo,Kim, Seok-Beom,Lee, Kyeong-Soo,Yun, Sung-Ho 대한예방의학회 2001 예방의학회지 Vol.34 No.4
Objectives : To assess the prevalence of knee osteoarthritis through proper diagnosis in a rural community and to elucidate the relevant factors of this health problem in order to develop educational methods for the prevention of female knee osteoarthritis as well to provide basic data for prospective research. Methods : Over a period of three months starting from August, 2000, 432 women over the age of 40 and living in a rural area were selected by a multistage cluster sampling method in order to investigate the prevalence of knee osteoarthritis and the related factors. The study utilized interviews and radiological examination. The criteria of knee osteoarthritis used was the American College of Rheumatology classification criteria for osteoarthritis of the knee(1995). Results : The adjusted prevalence of knee osteoarthritis among the subjects was 55.0%, and multiple logistic regression analysis showed that the odds ratio(OR) of knee osteoarthritis among subjects 50-59 years of age and subjects older than 60 years of age as compared to subjects 40-49 years of age were 2.43(95% CI: 1.30-4.70) and 4.40(95% CI: 2.47-7.83), respectively. The OR of knee osteoarthritis among factory workers or farmers as compared to others was 1.79(95% CI: 1.03-3.12). The OR of knee osteoarthritis among subjects who had a family history and subjects who had knee injury or surgical history against those subjects had neither were 2.56(95% CI: 1.42-4.03) and 4.70(95% CI:1.45-15.19), respectively. The OR of knee osteoarthritis among smokers against non smokers was 0.47(95% CI: 0.22-0.97). Conclusions : Related factors of knee osteoarthritis included age, occupation, family history, smoking, knee injury and history of surgery In order to prevent knee osteoarthritis in high risked rural woman, education concerning self-care methods and safety guideline must be provided at the work place by the public and private health sectors. Additionally, these women should be continually encouraged to exercise, including jogging and swimming regularly.
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이동수,이경수,강복수 영남대학교 의과대학 1993 Yeungnam University Journal of Medicine Vol.10 No.2
대구시내 1개 국민학교 4학년 284명(남아 144명, 여아 140명)을 대상으로, 1992년 5월에 일반적인 특성을 조사하였고, 체격, 체지방 및 혈압을 측정하였으며, 혈액의 생화학적 검사를 실시하여 혈압과 관련된 요인을 분석하였다. 대상자의 평균 수축기 혈압은 103.5㎜Hg였으며, 남아가 104.1㎜Hg, 여아가 102.9㎜Hg로 남아가 약간 높게 나타났으며, 평균 확장기 혈압은 67.1㎜Hg이고, 남아가 66.6㎜Hg, 여아가 67.5㎜Hg로 여아가 약간 높았다. 수축기 및 확장기 혈압을 종속변수로 총콜레스테롤, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤, 중성지방, 총단백질, 요산, 혈당, Rohrer지수, 체지방 비율, 체지방 무게 및 제지방 체중을 독립변수로 하여 상관관계와 중회귀분석을 실시하였다. 수축기 및 확장기혈압과 독립변수들과의 상관관계를 성별에 따라 분석한 결과 남아의 수축기 혈압은 신장, 체중, Rohrer지수, 제지방 체중, 체지방 무게 및 중성지방과 유의한 상관관계가 있었으며(p<0.01), 여아의 수축기혈압은 신장, 체중, 제지방체중 및 요산과 유의한 상관관계가 있었다(p<0.01). 남아의 확장기혈압은 체중, Rohrer지수 및 제지방체중과 유의한 상관관계가 있었으며(p<0.01), 여아의 확장기혈압은 체중, 제지방체중(p<0.01), 신장, 체지방무게 및 총단백질(p<0.05)과 유의한 상관관계가 있었다. 수축기 혈압을 종속변수로 한 중회귀분석에서 남아는 Rohrer지수와 sodium이 유의한 변수였고, 여아는 요산, Rohrer지수 및 체지방 비율이 유의한 변수였다. 확장기 혈압에서 남아는 Rohrer지수가 유의한 변수였고, 여아는 총단백질이 유의한 변수였다. 이상의 결과로 보아 소아의 혈압에 영향을 미치는 인자로는 Rohrer지수와 sodium, 요산, 총단백질 및 체지방 비율 이었고, 그 중 Rohrer지수가 가장 중요한 요인으로 인정되었다. 따라서 고혈압 발생을 예방하기 위해서는 비만, 식이 및 이와 관련된 생활양식의 개선과 이에 대한 보건교육이 요망된다. This study was conducted to identify the factors related to the blood pressure in school children. The study subjects were 144 boys and 140 girls aged 10 years old, 4th grade student of one elementary school in Taegu City. Blood pressure and 18 variables for 284 school children were measured in May 1992. A weight-for-height index, Rohrer index(weight/height³) was calculated for each individual as a measure of obesity. Body fat percent, fat weight, and lean body mass were measured by impedance fat meter(Model SIF-891). Serum total cholesterol, high-density lipoprotein, triglyceride, uric acid, total protein, and electrolyte were measured by automated clinical chemistry analyzer(Hitachi 4020). Low-density lipoprotein and atherogenic index were calculated by the equation. The variables assessed were sex, systolic blood pressure, diastolic blood pressure, Rohrer index, body fat percent, body fat weight, lean body mass, total cholesterol, high-density lipoprotein, low-density lipoprotein, uric acid, total protein, serum electrolyte and blood glucose. The mean systolic and diastolic blood pressures for boys were 104.1㎜Hg and 66.6㎜Hg and those for girls were 102.9㎜Hg and 67.5㎜Hg. Systolic blood pressure of boys was positively correlated with height, weight, Rohrer index, fat weight, lean body mass, and triglyceride. Systolic blood pressure of girls was positively correlated with height, weight, lean body mass, and uric acid. Diastolic blood pressure of boys was positively correlated with weight, Rohrer index, and lean body mass. Diastolic blood pressure of girls was positively correlated with height, weight, fat weight, and lean body mass and negatively with total serum protein. In multiple regression analysis for the systolic blood pressure, the significant independent variables were Rohrer index and serum sodium in boys, and serum uric acid, fat percent, and Rohrer index in girls. In multiple regression analysis of the diastolic blood pressure, the significant independent variables were Rohrer index in boys and total serum protein in girls. This study indicated that important factors influencing blood pressure in school children were Rohrer index, fat percent, serum sodium, uric acid, and total protein. Rohrer index was most important among these. It is recommended to enforce the nutritional education for diet control of obesity to prevent hypertention in children and to adopt healthy life-styles that promote good health and prevent development cardiovascular risk factors.
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