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Systemic Lupus Erythematosus를 동반한 Multiple sclerosis
이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.
권희석,이승휘,권순욱,주원남,박은호 漢陽大學校 環境科學硏究所 1991 環境科學論文集 Vol.12 No.-
신도시 계획에 따른 환경파괴 및 변화가 예상되는 분당지구의 어족자원을 보호하기 위하여 신도시 건설이전의 어류분포상을 조사하였다. 분당지구에는 잉어과 8종, 기름종개과 4종, 메기과, 뱀장어과, 송사리과, 드렁허리과, 극락어과, 구굴무치과 및 둑중개과 각 1 종을 포함하여 9 개과 19종이 분포하고 있었다. 최근 환경오염으로 감소추세에 있는 송사리, 드렁허리 및 버들 붕어가 이 지역에 존재한다는 것은 주목할 만한 것으로 특히 늪말지역의 늪지대는 신도시 건설 후에도 현재의 환경을 보존하여 이 지역 초, 중, 고등학교의 어류생태학 교육장으로 활용함이 좋을 것이다. 따라서 이 지역의 각별한 보호와 분별있는 개발이 요망된다. The freshwater fish fauna of Bundang Region, Kyungki-do, Korea, where dramatic environmental changes will be expected due to new city project, was censused to establish base line data for natural conservation program. Nineteen species belonging to 9 families were collected in this region. They were mainly cyprinids and cobitids. The Oryzias latipes, Monopterus albus, and Macropodus chinensis which are rare fish in recent years were found in this region. A swamp region called Neupmal is of particular interest in ichthyology excursion site for primary, middle and high school boy. Therefore, careful organization of new city plan and preservation of ichthyological fauna are strongly recommended.
Sensitivity Analysis of Amino Acids in Simulated Moving Bed Chromatography
Lee, Ju-Weon,Lee, Chong-Ho,Koo, Yoon-Mo The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.2
We conducted a sensitivity analysis of the simulated moving bed (SMB) chromatography with the case model of the separation of two amino acids phenylalanine and tryptophan. We consider a four-zone SMB chromatography where the triangle theory is used to determine the operating conditions. Competitive Langmuir isotherm model was used to determine the adsorption isotherm. The finite difference method is used to solve nonlinear partial differential equation (PDE) systems numerically. We examined the effects of alterations in the operating conditions(feed-extract, feed-raffinate, eluent-extract, eluent-raffinate, recycle, and switching time) and the adsorption isotherm parameters (Langmuir isotherm parameters a and b) on SMB efficiency. The variation range of operating conditions and Langmuir isotherm a was between -50 and 50% of original value and the variation range of the Langmuir isotherm b was between $2.25^{-5}$ and $2.25^5$ times of original value.
( Weon Ju Lee ),( Sang Lim Kim ),( Yoon Seok Choe ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4
Background: Acne is an inflammatory skin disorder caused by inflammatory biomarkers. Magnesium ascorbyl phosphate (MAP) is a stable precursor of vitamin C. It achieves a constant delivery of vitamin C into the skin and has antioxidative effects. Objective: We performed this study to evaluate the effect of MAP on the expression of inflammatory biomarkers in cultured sebocytes. Methods: Reverse transcription- polymerase chain reaction (RT-PCR) and enzyme- linked immunosorbent assay were performed for inflammatory cytokines and matrix metalloproteinases (MMPs) before and after treatment of cultured sebocytes with MAP (10-2 M), lipopolysaccharide (LPS) (5 μg/ml) and a combination of MAP and LPS. RT-PCR and western blotting were also performed for antimicrobial peptides (AMPs) and Toll-like receptor (TLR)-4 before and after treatment of cultured sebocytes with MAP, LPS, and a combination of MAP and LPS. Quantification of lipid peroxidation was also conducted. Results: The increased expression of inflammatory cytokines after treatment of cultured sebocytes with LPS was decreased after treatment with MAP. MMPs, AMPs, and TLR-4 were decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS, and increased after treatment of cultured sebocytes with LPS alone. Lipid peroxidation was significantly decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS. MAP decreased the increased lipid peroxidation after treatment of cultured sebocytes with LPS. Conclusion: MAP may be an effective alternative agent to improve inflammatory reactions in acne. (Ann Dermatol 27(4) 376∼382, 2015)
( Weon Ju Lee ),( Hyun Bo Sim ),( Sang Lim Kim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Kyung Chan Kim ),( Soon Ho Yim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: 5-aminolevulinic acid (5-ALA) stimulates murine hair growth in vivo study. Glycyl- Histidyl-Lysine (GHK) peptide increases hair follicle size and stimulates stem cell proliferation. Objectives: To investigate the efficacy of a combination of 5-ALA and GHK peptide (ALAVAX) on hair growth Methods: Cell culture of keratinocyte, melanocytes and fibroblast was performed for MTT assay. Seven-week old C57BL/6N mice were treated with 100 mg/ml ALA ± 5-minute red or blue LED or 100 mg/ml ALAVAX ± 5-minute red or blue LED once a day for 24 days for evaluation of hair growth. Cultured human hair organs were treated with 100 times-diluted ALAVAX ± 20-minute red LED for 7 days. Forty five patients with male pattern hair loss were treated with ALAVAX once a day for 6 months. Total hair count, hair diameter, hair length and patients’ assessment were evaluated at week 4, 12 and 24 after treatment. The penetration of ALAVAX into hair follicles was examined under the fluorescent microscopy. Results: Hair growth was most conspicuous in mice treated with ALAVAX + red LED. Hair growth of cultured hair organs was significantly increased after treatment with ALAVAX only. Total hair count, hairlength and patients’ assessment in humans was significantly improved in the group treated with ALAVAX. No adverse event was reported. The penetration of ALAVAX in human hair follicles was prominent. Conclusion: ALAVAX could be considered as one of the useful agents for the treatment of male pattern hair loss.