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Effect of Mn and C on Age Hardening of Fe–Mn–Al–C Lightweight Steels
Sung‑Won Park,Jun Young Park,Kyong Mox Cho,Jae Hoon Jang,Seong‑Jun Park,Joonoh Moon,Tae‑Ho Lee,Jong‑Ho Shin 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3
The effects of Mn and C content on the age hardening of Fe–Mn–Al–C lightweight steels, which have austenitic or duplex(austenite and ferrite) microstructures, were investigated. An increase in Mn content induced a delay of the age hardeningthat is caused by the formation of intra-granular κ-carbides. In order to interpret the effect of Mn content, first-principlescalculations were conducted using the supercells of Fe24Al8C8,Fe24Al8C7,Fe24(Al7Mn)C8, and Fe24(Al7Mn)C7. The calculationsshowed that an increase in Mn content could be the source of the delay of the intra-granular κ-carbide formation bysuppressing C atom’ occupation of the vacancy at the body-centered site of L12. An increase in C content accelerated theformation of intra-granular κ-carbides, which induced the intense age hardening, and coarse inter-granular κ-carbides, whichresulted in significant decrease in impact absorbed energy due to inter-granular fracture.
An analysis of characteristics of pigmented fungiform papillae of the tongue: single center study
( Sung-min Park ),( Tae-wook Kim ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk Ryu ),( Woo-haing Shim ),( Gun-wook Kim ),( Byung-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Hoon-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Pigmented fungiform papillae of the tongue (PFPT) is a rare benign pigmentary disorder of the tongue. In dark-skinned individuals, PFPT appears to be relatively common. However, limited data exist on PFPT in Korean patients. Objectives: To investigate the clinical characteristics of PFPT in Korean patients Methods: Patients diagnosed with PFPT between 1995 and 2016 at Pusan National University Hospital were included. Clinical characteristics of PFPT, dermoscopic findings, and comorbidities were reviewed. Results: Eighteen patients diagnosed as PFPT were enrolled. Male to female ratio was 1 : 5. The mean age at diagnosis was 39.6 years (range, 8-65 years). According to Holzwanger’s classification, type I was the most common (88.9%). PFPT was commonly concomitant with pigmentary disorders including mucosal melanotic macules, Laugier-Hunziker syndrome, Melasma, and melanonychia (6/18, 33.3%). Preceding oral inflammatory lesions were found in 3 patients (16.7%), and systemic diseases and infectious diseases existed in 2 patients respectively (11.1%). Dermoscopic examination was performed in 7 patients; Pigmented border with dichotomized vessels (Rose petal pattern, 71.4%), and diffuse pigmentation (cobblestone pattern, 57.1%) were common findings. Conclusion: Our study shows PFPT can coexist with pigmentary disorder. Female predominance, concomitant pigmentary disorders of PFPT shows sex hormone or susceptibility to abnormal pigmentation may play a role in pathogenesis of PFPT.
Case Report : Portal biliopathy treated with endoscopic biliary stenting
( Sung Jin Jeon ),( Jae Ki Min ),( So Young Kwon ),( Jun Hyun Kim ),( Sun Young Moon ),( Kang Hoon Lee ),( Jeong Han Kim ),( Won Hyeok Choe ),( Young Koog Cheon ),( Tae Hyung Kim ),( Hee Sun Park ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.1
Portal biliopathy is defined as abnormalities in the extra- and intrahepatic ducts and gallbladder of patients with portal hypertension. This condition is associated with extrahepatic venous obstruction and dilatation of the venous plexus of the common bile duct, resulting in mural irregularities and compression of the biliary tree. Most patients with portal biliopathy remain asymptomatic, but approximately 10% of them advance to symptomatic abdominal pain, jaundice, and fever. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are currently used as diagnostic tools because they are noninvasive and can be used to assess the regularity, length, and degree of bile duct narrowing. Management of portal biliopathy is aimed at biliary decompression and reducing the portal pressure. Portal biliopathy has rarely been reported in Korea. We present a symptomatic case of portal biliopathy that was complicated by cholangitis and successfully treated with biliary endoscopic procedures. (Clin Mol Hepatol 2016;22:172-176)
ANALYSIS OF PRESTRESSED CONCRETE CONTAINMENT VESSEL(PCCV) UNDER SEVERE ACCIDENT LOADING
SANG HOON NOH,IL HWAN MOON,JONG BO LEE,JONG HAK KIM 한국원자력학회 2008 Nuclear Engineering and Technology Vol.40 No.1
This paper describes the nonlinear analyses of a 1:4 scale model of a prestressed concrete containment vessel (PCCV) using an axisymmetric model and a three-dimensional model. These two models are refined by comparison of the analysis results and with testing results. This paper is especially focused on the analysis of behavior under pressure and the temperature effects revealed using an axisymmetric model. The temperature-dependent degradation properties of concrete and steel are considered. Both geometric and material nonlinearities, including thermal effects, are also addressed in the analyses. The Menetrey and Willam (1995) concrete constitutive model with non-associated flow potential is adopted for this study. This study includes the results of the predicted thermal and mechanical behaviors of the PCCV subject to high temperature loading and internal pressure at the same time. To find the effect of high temperature accident conditions on the ultimate capacity of the liner plate, reinforcement, prestressing tendon and concrete, two kinds of analyses are performed: one for pressure only and the other for pressure with temperature. The results from the test on pressurization, analysis for pressure only, and analyses considering pressure with temperatures are compared with one another. The analysis results show that the temperature directly affects the behavior of the liner plate, but has little impact on the ultimate pressure capacity of the PCCV.
[P212] A case of pigmentary mosaicism associated with diploid/triploid mixoploidy
( Sung-min Park ),( Sang-jin Cheon ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Pigmentary mosaicism (PM) is characterized by cutaneous manifestations that are hypo- and hyperpigmented macules in a streaky configuration along the lines of Blaschko. Chromosomal mosaicism has been reported in many cases of PM. Among these cases, diploid/triploid mixoploidy (DTM) is extremely rare. A 21-month-old girl was referred to dermatology clinic for evaluation of skin pigmentation. She was born at 37 weeks of gestation following caesarean section because of severe intrauterine growth retardation, and her birth weight was 1.49 kg (below the 5th percentile). Physical examination revealed dysmorphic features including hypertelorism, microretrognathia, low-set ears, macrocephaly, brachydactyly, clinodactyly, and hypodontia. Neurological examinations revealed generalized hypotonia, and Bailey developmental assessment detected global developmental delay. Karyotyping of peripheral blood lymphocytes showed a normal karyotype. Additionally, karyotyping of fibroblasts from hyperpigmented patch was performed, and the results revealed triploidy (69, XXX). Clinical findings, and the results of cytogenetic studies in our patient were consistent with those of PM associated with DTM. Pigmentary skin change with neurological and morphological abnormalities could be a sign of karyotypic abnormality. In this situation, obtaining a skin biopsy for karyotyping of could be helpful to understand the underlying genetic abnormalities.
[P404] Cervical chondrocutaneous branchial remnant
( Sang-jin Cheon ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Gun-wook Kim ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyang-suk You ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Cervical chondrocutaneous branchial remnants (CCBRs) are rare developmental anomalies of the branchial apparatus. They are derived from dislocated branchial apparatus component comprised of cartilage tissues. They are clinically asymptomatic protruding papule and nodule, and typically located in the middle or lower third of anterior border of the sternocleidomastoid muscle. The patient was a 44-year-old female who presented with solitary asymptomatic skin-colored nodule on the left side of neck. The patient denied any history of trauma, operation and injection history. Physical examination revealed no remarkable findings except for the skin lesion. Ultrasonographic finding showed 8 x 3mm hyperechoic nodule on subcutaneous layer and the lesion was not connected to underlying structure. Histopathological examination after surgical excision showed hyaline cartilage core in the dermis without connection to epidermis. A diagnosis of CCBRs was confirmed, and the patient showed no recurrence during 9 months of follow up Herein, we present a rare case of CCBRs composed of hyaline cartilage. Dermatologist should consider CCBRs in the differential diagnosis of the skin lesion associated with neck nodule.
Cancer Cachexia in Pancreatic Cancer Patients: Recent Advances and New Therapeutic Approach
Sang Hoon Lee,Moon Jae Chung Korean Society of Gastrointestinal Cancer 2015 Journal of digestive cancer reports Vol.3 No.2
About 80% of all pancreatic cancer patients suffer from a wasting syndrome defined as the cancer cachexia characterized by abnormally low weight, weakness, and loss of skeletal muscle mass, which directly impacts physical activity, quality of life and overall survival. Over the past decades, we have gained new insights into the underlying mechanism of cachexia associated with pancreatic cancer. The aim of this review was to explore recent findings about cancer cachexia pathophysiology and describe the current pharmacologic approach. Pancreatic cancer cachexia is a multifactorial syndrome mediated by mechanical factors, inflammatory cytokines, neuropeptides, hormones and tumor-derived factors. The treatment of cancer cachexia remains controversial but is currently an active area of research. Several new targeted drugs are under investigation, and we hope to open a new prospect in the management of cancer cachexia in the future.
[P402] Primary milium of the nipple
( Sung-min Park ),( Hak-jun Kim ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Milia are very common, benign, keratin-filled, small epidermal inclusion cysts measuring 1-2 mm in diameter that may arise from the pilosebaceous apparatus or the eccrine sweat ducts. They occur either spontaneously (primary milia) or secondary to various processes (secondary milia). Primary milia are common in newborns, and resolve spontaneously within weeks to several months. They can be found anywhere, but usually occur on the face, upper trunk, and extremities. However, milia occurring on the nipple are rare. Herein, we present an interesting case of primary milium of nipple. A 6-year-old boy presented with a solitary, pearly, dome-shaped nodule on the left nipple. His mother stated that the lesion had been present at birth, and there was no history of trauma, and prior skin lesions. There were no associated signs or symptoms, and his contralateral breast was normal. Cyst was excised under local anesthesia, and histopathologic findings were consistent with milium.
Sang Hoon Lee,Moon Jae Chung Korean Society of Gastrointestinal Cancer 2014 Journal of digestive cancer reports Vol.2 No.1
We report a patient with combined hepatocellular-cholangiocarcinoma confined in the common hepatic duct and scirrhous type of hepatocellular carcinoma in the caudate lobe of liver simultaneously. The patient was a 55-yearsold Korean man with hepatitis B virus (HBV) carrier who was referred from a local hospital due to detected liver mass on abdominal computed tomography (CT). He has presented jaundice and weight loss for the previous 3 weeks. Laboratory examination showed AST/ALT elevation and hyperbilirubinemia. HBsAg was positive. The tumor marker study showed elevated AFP and DCP, not CEA and CA 19-9. Abdominal CT disclosed an about 2.1×0.9 cm sized soft tissue density in hilum with both intrahepatic duct (IHD) dilatations and an about 3×2.1 cm sized arterial enhancing lesion at segment 8 of the liver. Patient received 15 cycles of Gemcitabine/Cisplantin chemotherapy from February 27, 2013 to December 31, 2013. Caudate lobectomy of liver, segmental resection of bile duct and Roux-en-Y hepaticojejunostomy was performed on February 10, 2014. The final pathologic report showed double primary liver cancer, combined hepatocellular-cholangiocarcinoma in common hepatic bile duct and scirrhous type of hepatocellular carcinoma in segment 1 of the liver. This is a very unusual case in which combined hepatocellular-cholangiocarcinoma confined in the large bile duct and two rare hepatic cancers coexisted.