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RISS 인기검색어
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- 저자 : ( Kentaro Iwata ) (검색결과 4 건)
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( Daisuke Takamura ),( Kentaro Iwata ),( Tatsuya Sueyoshi ),( Tadashi Yasuda ),( Hideki Moriyama ) 대한슬관절학회 2021 대한슬관절학회지 Vol.33 No.-
Background: Physical activity is associated with physical function; however, the relationship between early physical activity after total knee arthroplasty (TKA) and postoperative physical function remains unclear. The purpose of this study was to evaluate the association of early physical activity after TKA with postoperative physical function. Methods: Timed Up and Go test (TUG) of 47 patients was assessed preoperatively and at 10 days, 3 months, and 6 months postoperatively. Physical activity from the second to the ninth day after TKA was measured with accelerometer, and the correlation with pre- and postoperative physical function was evaluated . A multiple linear regression was used to predict TUG at 6 months after TKA. Results: Postoperative physical activity correlated with preoperative TUG (ρ = -0.485, p < 0.001), TUG at 10 days (ρ = -0.675, p < 0.001), 3 months (ρ = -0.441, p < 0.01), and 6 months (ρ = -0.368, p < 0.05) after surgery. Multiple linear regression indicated that only the preoperative TUG was associated with TUG at 6 months. Postoperative physical activity was not an independent factor predicting TUG at 6 months after TKA. Conclusion: Our study demonstrated that patients with better physical function have higher physical activity in the early postoperative period, whereas it does not affect physical function at 6 months after TKA. In the early postoperative period, increasing physical activity may not always be necessary to improve postoperative physical function. We also confirmed that preoperative physical function affects postoperative physical function. These findings may be beneficial in improving rehabilitation programs in the early postoperative period.
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Amano Norihiko,Iwata Kentaro,Iwata Sachiyo 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4
Background: Neutralizing antibody cocktail therapy, REGN-COV2, is promising in preventing a severe form of coronavirus disease 2019 (COVID-19), but its effectiveness in Japan has not been fully investigated. Materials and Methods: To evaluate the effectiveness of REGN-COV2, clinical data of 20 patients with COVID-19 who received REGN-COV2 was compared with the control by matching age and sex. The primary outcome was the time from the onset to defervescence, the duration of hospitalization, and oxygen requirement. A sensitivity analysis using Bayesian analysis was also conducted. Results: The time to defervescence was significantly shorter in the treatment group (5.25 vs. 7.95 days, P = 0.02), and so was the duration of hospitalization (7.115 vs. 11.45, P = 0.0009). However, the oxygen therapy requirement did not differ between the two groups (15% vs. 35%, P = 0.27). For Bayesian analysis, the median posterior probability of the time to defervescence since the symptom onset on the REGN-COV2 group was 5.28 days [95% credible interval (CrI): 4.28 - 6.31 days], compared with the control of 7.99 days (95% CrI: 6.81 - 9.24 days). The posterior probability of the duration of the hospitalization on the REGN-COV2 group was 7.17 days (95% CrI: 5.99 - 8.24 days), compared with the control of 11.54 days (95% CrI: 10.28 - 13.14 days). The posterior probability of the oxygen requirement on the REGN-COV2 group was 18% (95% CrI: 3 - 33%), compared with the control of 36% (95% CrI: 16 - 54%). Conclusion: REGN-COV2 may be effective in early defervescence and shorter hospitalization. Its effectiveness for preventing a severe form of infection needs to be evaluated by further studies.
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Ohkubo, Kei,Mizushima, Kentaro,Iwata, Ryosuke,Fukuzumi, Shunichi Royal Society of Chemistry 2011 Chemical Science Vol.2 No.4
<P>Photocatalytic bromination of aromatic hydrocarbons by molecular oxygen with hydrogen bromide occurs efficiently to produce monobrominated products selectively using 9-mesityl-10-methylacridinium ion (Acr<SUP>+</SUP>–Mes) as a photocatalyst under visible light irradiation. Both the product yield and selectivity for the bromination of 1,3,5-trimethoxybenzene were 100% with a quantum yield of 4.8%. The photocatalytic turnover number is 900 based on the initial concentration of Acr<SUP>+</SUP>–Mes. The reactive radical intermediates involved in the photocatalytic cycle have been successfully detected by laser flash photolysis measurements. The photocatalytic bromination is initiated by photoinduced electron transfer from the mesitylene moiety to the singlet excited state of acridinium ion, which results in formation of the electron-transfer state of Acr<SUP>+</SUP>–Mes (Acr˙–Mes˙<SUP>+</SUP>), followed by electron transfer from aromatic hydrocarbons to the mesitylene radical cation moiety and electron transfer from the acridinyl radical moiety to O<SUB>2</SUB>. The resulting radical cations of aromatic hydrocarbons react with Br<SUP>−</SUP> to produce the corresponding monobrominated products selectively.</P> <P>Graphic Abstract</P><P>Photocatalytic bromination of aromatic hydrocarbons by O<SUB>2</SUB> with HBr occurs efficiently to produce the monobrominated products using 9-mesityl-10-methylacridinium ion. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0sc00535e'> </P>
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Ohkubo, Kei,Mizushima, Kentaro,Iwata, Ryosuke,Souma, Kazunori,Suzuki, Nobuo,Fukuzumi, Shunichi Royal Society of Chemistry 2010 Chemical communications Vol.46 No.4
<P>Photooxygenation of <I>p</I>-xylene by oxygen occurs efficiently under photoirradiation of 9-mesityl-2,7,10-trimethylacridinium ion (Me<SUB>2</SUB>Acr<SUP>+</SUP>–Mes) to yield <I>p</I>-tolualdehyde and hydrogen peroxide, which is initiated <I>via</I> photoinduced electron transfer of Me<SUB>2</SUB>Acr<SUP>+</SUP>–Mes to produce the electron-transfer state.</P> <P>Graphic Abstract</P><P>Photooxygenation of <I>p</I>-xylene by oxygen occurs efficiently under photoirradiation of mesitylacridinium in an O<SUB>2</SUB>-saturated acetonitrile solution to yield <I>p</I>-tolualdehyde and hydrogen peroxide. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b920606j'> </P>
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