The CR SPR/Cas9-Generated HEAD NG DATE 3a Mutation Enhances Leaf Production in Perilla frutescens

Sivabalan Karthik(Sivabalan Karthik),Jae Bok Heo(Jae Bok Heo) 한국육종학회 2023 한국육종학회 공동학술발표집 Vol.2023 No.-

Sonochemical fabrication of petal array-like copper/nickel oxide composite foam as a pseudocapacitive material for energy storage

Karthik, Namachivayam,Edison, Thomas Nesakumar Jebakumar Immanuel,Sethuraman, Mathur Gopalakrishnan,Lee, Yong Rok Elsevier BV * North-Holland 2017 Applied Surface Science Vol.396 No.-

<P><B>Abstract</B></P> <P>Copper/nickel oxide composite foam (Cu/Ni) with petal array-like textures were successfully fabricated via a facile sonochemical approach, and its applications as a pseudocapacitive material for energy storage were examined. The nickel foam was immersed into a mixture of copper chloride (CuCl<SUB>2</SUB>) and hydrochloric acid (HCl) and subsequently sonicated for 30min at 60°C. As a result of galvanic replacement, nickel was oxidized while copper was reduced, and the walls of the nickel foam were coated with copper particles. Studies using field emission scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopic analyses confirmed the morphology and chemical structure of the as-obtained Cu/Ni oxide composite foam. The supercapacitive performance of the as-fabricated Cu/Ni oxide composite foam was evaluated in 2M KOH by employing cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy analyses. Cyclic voltammograms revealed that the Cu/Ni oxide composite foam exhibited pseudocapacitive behavior and delivered a high specific capacitance of 1773Fg<SUP>−1</SUP> at a scan rate of 5mVs<SUP>−1</SUP>. This improvement may be attributed to the morphology, surface functionalization with heteroatoms, hydrogen evolution, and high conductivity, along with the low resistance due to short path lengths for electron transportation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A composite Ni foam textured with Cu particles was fabricated by a sonication method. </LI> <LI> The foam can be used as a pseudocapacitive material for energy storage applications. </LI> <LI> The foam has a high specific capacitance of 1773Fg<SUP>−1</SUP> at a scan rate of 5mVs<SUP>−1</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Responsiveness of Commonly Used Patient-Reported Outcome Instruments in Lumbar Microdiscectomy

Karthik Vishwanathan,Ian Braithwaite 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.5

Study Design: Prospective observational cohort study. Purpose: To evaluate the comparative responsiveness of Oswestry Disability Index (ODI, version 2.0), 24-item Roland-Morris Disability Questionnaire (RMDQ), 12-item Short-Form Health Survey (SF-12) physical component score (PCS), and SF-12 mental component score (MCS) in patients that underwent micro-discectomy for lumbar disc herniation. Overview of Literature: Responsiveness is a context specific term and no study has reported the responsiveness of ODI version 2.0, RMDQ, SF-12 PCS, or SF-12 MCS in discectomy patients. Methods: Responsiveness was assessed using distribution-based methods (effect size [ES], standardized response means [SRM], SRM difference between patients who improved and those who did not show improvement [SRM difference]), and the anchor-based method (area under the curve [AUC] of receiver operating characteristic curves). Values of ES and SRM higher than 0.8, and AUC value higher than 0.7 suggest adequate responsiveness. Outcome instrument demonstrating the highest value of SRM difference and AUC was considered the most responsive. Results: Responsiveness was assessed in 98 participants at a mean follow-up time of 12 weeks postoperatively. The overall ES of RMDQ, ODI, SF-12 PCS, and SF-12 MCS was 2.15, 2.11, 2.08, and 0.86, respectively. The overall SRM of ODI, RMDQ, SF-12 PCS, and SF-12 MCS was 1.36, 1.43, 1.24, and 0.65, respectively. The SRM difference in RMDQ, ODI, SF-12 PCS, and SF-12 MCS was 2.64, 2.26, 1.32, and 1.29, respectively. The AUC of ODI, RMDQ, SF-12 PCS, and SF-12 MCS was 0.96, 0.96, 0.83, and 0.83, respectively. Conclusions: ODI, RMDQ, SF-12 PCS, and SF-12 MCS demonstrated adequate responsiveness in a homogenous cohort of patients who underwent lumbar micro-discectomy. ODI and RMDQ are equally responsive and, thus, are interchangeable instruments for region specific outcomes. Both the SF-12 PCS and SF-12 MCS can assess the quality of life following lumbar micro-discectomy.

Carbon-allotropes: synthesis methods, applications and future perspectives

Karthik, P.S.,Himaja, A.L.,Singh, Surya Prakash 한국탄소학회 2014 Carbon Letters Vol.15 No.4

The element carbon has been used as a source of energy for the past few hundred years, and now in this era of technology, carbon has played a significant and very prominent role in almost all fields of science and technology. So as an honour to this marvellous element, we humans should know about its various forms of existence. In this review article, we shed light on all possible carbon-allotropes; similarities in their synthesis techniques and the starting materials; their wide range of possible availability; and finally, future perspectives and applications. A brief introduction is given on the types, structures, and shapes of the allotropes of carbon for a better understanding.

Evolving live load criteria in bridge design code guidelines - A case study of India based on IRC 6

Karthik, P.,Sharma, Shashi Kant,Akbar, M. Abdul Techno-Press 2022 Structural monitoring and maintenance Vol.9 No.1

One of the instances which demand structural engineer's greatest attention and upgradation is the changing live load requirement in bridge design code. The challenge increases in developing countries as the pace of infrastructural growth is being catered by the respective country codes with bigger and heavier vehicles to be considered in the design. This paper presents the case study of India where Indian Roads Congress (IRC) codes in its revised version from 2014 to 2017 introduced massive Special vehicle (SV) around 40 m long and weighing 3850 kN to be considered in the design of road bridges. The code does not specify the minimum distance between successive special vehicles unlike other loading classes and hence the consequences of it form the motivation for this study. The effect of SV in comparison with Class 70R, Class AA, Class A, and Class B loading is studied based on the maximum bending moment with moving load applied in Autodesk Robot Structural Analysis. The spans considered in the analysis varied from 10 m to 1991 m corresponding to the span of Akashi Kaikyo Bridge (longest bridge span in the world). A total of 182 analyses for 7 types of vehicles (class B, class A, class 70R tracked, class 70R wheeled, class AA tracked, AA wheeled, and Special vehicle) on 26 different span lengths is carried out. The span corresponding to other vehicles which would equal the bending moment of a single SV is presented along with a comparison relative to Standard Uniformly Distributed Load. Further, the results are presented by introducing a new parameter named Intensity Factor which is proven to relate the effect of axle spacing of vehicle on the normalized bending moment developed.

Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review

Karthik Bommannan,Man Updesh Singh Sachdeva,Aravind Sekar,Rajender Kumar,Pranab Dey 대한혈액학회 2017 Blood Research Vol.52 No.3

Plasma cell leukemia in North India: retrospective analysis of a distinct clinicohematological entity from a tertiary care center and review of literature

Karthik Bommannan,Man Updesh Singh Sachdeva,Pankaj Malhotra,Narender Kumar,Prashant Sharma,Shano Naseem,Jasmina Ahluwalia,Reena Das,Neelam Varma,Gaurav Prakash,Alka Khadwal,Radhika Srinivasan,Subhash 대한혈액학회 2016 Blood Research Vol.51 No.1

BackgroundPlasma cell leukemia (PCL) is a rare and aggressive plasma cell neoplasm. In PCL, clonal plasma cells comprise ≥20% of the peripheral blood (PB) leukocytes and/or the absolute clonal PB plasma cell count is ≥2×109/L. Primary PCL (PPCL) originates de novo, whereas, secondary PCL (SPCL) evolves from pre-existing multiple myeloma.MethodsClinicohematological features, immunophenotypic profile, and survival of PCL patients were analyzed retrospectively.ResultsBetween January 2007 and December 2014, ten PPCL and four SPCL patients were inves-tigated (8 PPCLs and 3 SPCLs had complete clinical data). All were North Indians, sharing common geography and ethnicity. Our cohort showed less frequent renal failure, more frequent hepatomegaly, and non-secretory type disease. In contrast to western literature, flow cytometric immunophenotyping of our cohort revealed altered expression of CD138 (67%), CD56 (33%), and CD20 (0%). With novel therapeutic agents, these PPCL patients had a median overall survival of 15 months.ConclusionWe highlight that our PPCL patients from North India had distinct clinicohematological and immunophenotypic profiles. The significance of our findings must be tested in a larger patient cohort and must be supported by molecular and cytogenetic investigations to un-mask possible significant effects on pathogenesis.

Hemophagocytic lymphohistiocytosis secondary to histoplasmosis

Karthik Bommanan BK,Shano Naseem,Neelam Varma 대한혈액학회 2017 Blood Research Vol.51 No.2

Electro-synthesis of sulfur doped nickel cobalt layered double hydroxide for electrocatalytic hydrogen evolution reaction and supercapacitor applications

Karthik, Namachivayam,Edison, Thomas Nesakumar Jebakumar Immanuel,Atchudan, Raji,Xiong, Dangsheng,Lee, Yong Rok Elsevier 2019 Journal of electroanalytical chemistry Vol.833 No.-

<P><B>Abstract</B></P> <P>In this work, sulfur doped nickel cobalt layered double hydroxide nanosheet arrays are fabricated on a stainless steel (S-LDH/SS) substrate by simple electrodeposition technique for electrocatalytic hydrogen evolution reaction (HER) and supercapacitor applications. The surface morphology and chemical composition of S-LDH/SS are accessed by field emission electron microscopy (FE-SEM) with energy dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS), respectively. Remarkably, the fabricated S-LDH/SS electrode requires low overpotential of −0.38V vs. RHE to accomplish a current density of −10mAcm<SUP>−2</SUP> with a less Tafel slope of −69mVdec<SUP>−1</SUP> for HER in aqueous KOH. Further, the tailored S-LDH/SS behaves like a battery-type electrode and delivers maximum specific capacity of 344Cg<SUP>−1</SUP> (95.5mAhg<SUP>−1</SUP>) at scan rate of 5mVs<SUP>−1</SUP>, which possess excellent cyclic stability and capacity retention. The S-LDH/SS comprised by two types of active catalytic sites along with anions furnish an excellent conductivity, which improving the mass and ionic transportations. Hopefully, exceptional electrochemical interpretation substantiates that this S-LDH/SS electrode might be a favorable material for the energy conversion and storage applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sulfur doped nickel cobalt layered double hydroxide nano-arrays were electrodeposited on stainless steel (S-LDH/SS). </LI> <LI> S-LDH/SS displayed good electrochemical performance in KOH. </LI> <LI> S-LDH/SS required low onset and low overpotential for HER. </LI> <LI> S-LDH/SS delivered maximum specific capacity of 344Cg<SUP>−1</SUP> at 5mVs<SUP>−1</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Relevance of flow cytometric categorization and end-of-induction measurable residual disease assessment in pediatric and adult T-lymphoblastic leukemia patients

Karthik Bommannan,Jhansi Rani Arumugam,Venkatraman Radhakrishnan,Jayachandran Perumal Kalaiyarasi,Parathan Karunakaran,Nikita Mehra,Tenali Gnana Sagar,Shirley Sundersingh 대한혈액학회 2022 Blood Research Vol.57 No.3

Background T-lymphoblastic leukemia (T-ALL) patients expressing myeloid/stem cell antigens are classified as early T-cell precursor lymphoblastic leukemia (ETP-ALL) or near-ETP-ALL. Methods Clinico-laboratory profiles, flow cytometric end-of-induction measurable residual disease (EOI-MRD), and survival of treatment naïve T-ALL patients were analyzed according to their immunophenotypic subtypes. Results Among 81 consecutive T-ALL patients diagnosed, 21% (N=17) were ETP-ALL and 19% (N=15) were near-ETP-ALL. EOI-MRD was detectable in 39% of the 59 samples tested (31.6% of pediatric samples and 52.4% of adult samples). The frequency of EOI-MRD positivity was significantly higher among ETP-ALL (75%, P =0.001) and near-ETP-ALL (71%, P =0.009) patients compared to that in conventional-T-ALL (con-T-ALL) patients (22.5%). CD8 (P=0.046) and CD38 (P=0.046) expressions were significantly upregulated in the EOI blasts of con-T-ALL and ETP-ALL samples, respectively. The 2-year rates of overall (OS), relapse-free (RFS), and event-free survival (EFS) among the T-ALL patients (pediatric vs. adult) was 79.5% vs. 39.8% (P <0.001), 84.3% vs. 60.4% (P =0.026), and 80.3% vs. 38% (P <0.001), respectively. Univariate analysis revealed that 2-year EFS and RFS of pediatric T-ALL patients was independent of T-ALL subtype and was influenced only by EOI-MRD status. However, 2-year OS, RFS, and EFS among adult T-ALL patients were EOI-MRD independent and influenced only by the near-ETP-ALL phenotype. Conclusion Two-year survival among pediatric and adult T-ALL patients is attributed to EOI-MRD status and near-ETP-ALL phenotype, respectively.