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생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구
김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.
( Gun Wook Kim ),( Seung Wook Jwa ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4
A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened dramatically during therapy. Because of the extensive skin eruptions, he stopped therapy for chronic hepatitis C and subsequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate ointment. After this, the psoriasis improved in a slow but comprehensive manner. Our case suggests that physicians should keep in mind the possibility of psoriasis as a side effect of interferon treatment for chronic hepatitis C. (Ann Dermatol 25(4) 479∼482, 2013)
( Gun-yoon Shin ),( Sung-sam Hong ),( Dong-wook Kim ),( Cheol-hun Hwang ),( Myung-mook Han ),( Hwayoung Kim ),( Young Jae Kim ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.7
Beaches have many risk factors that cause various accidents, such as drifting and drowning, these accidents have many risk factors. To analyze them, in this paper, we identify beach risk factors, and define the criteria and correlation for each risk factor. Then, we generate new risk factors based on Fuzzy theory, and define Situation Awareness for each time. Finally, we propose a beach risk assessment and prediction model based on linear regression using the calculated risk result and pre-defined risk factors. We use national public data of the Korea Meteorological Administration (KMA), and the Korea Hydrographic and Oceanographic Agency (KHOA). The results of the experiment showed the prediction accuracy of beach risk to be 0.90%, and the prediction accuracy of drifting and drowning accidents to be 0.89% and 0.86%, respectively. Also, through factor correlation analysis and risk factor assessment, the influence of each of the factors on beach risk can be confirmed. In conclusion, we confirmed that our proposed model can assess and predict beach risks.
Kim, Jae Kyeom,Shin, Eui-Cheol,Lim, Ho-Jeong,Choi, Soo Jung,Kim, Cho Rong,Suh, Soo Hwan,Kim, Chang-Ju,Park, Gwi Gun,Park, Cheung-Seog,Kim, Hye Kyung,Choi, Jong Hun,Song, Sang-Wook,Shin, Dong-Hoon Hindawi Publishing Corporation 2015 Journal of analytical methods in chemistry Vol.2015 No.-
<P>Few studies have investigated <I>Seomae</I> mugwort (a Korean native mugwort variety of <I>Artemisia argyi</I> H. Lév. & Vaniot), exclusively cultivated in the southern Korean peninsula, and the possibility of its use as a food resource. In the present study, we compared the nutritional and chemical properties as well as sensory attributes of <I>Seomae</I> mugwort and the commonly consumed species <I>Artemisia princeps</I> Pamp. In comparison with <I>A. princeps, Seomae</I> mugwort had higher contents of polyunsaturated fatty acids, total phenolic compounds, vitamin C, and essential amino acids. In addition, <I>Seomae</I> mugwort had better radical scavenging activity and more diverse volatile compounds than <I>A. princeps</I> as well as favorable sensory attributes when consumed as tea. Given that scant information is available regarding the <I>Seomae</I> mugwort and its biological, chemical, and sensory characteristics, the results herein may provide important characterization data for further industrial and research applications of this mugwort variety.</P>
( Gun Wook Kim ),( Hyun Je Park ),( Hoon Soo Kim ),( Su Han Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Herein, we report a case of an 8-year-old girl with dapsone hypersensitivity syndrome (DHS) that occurred during the treatment of erythema elevatum diutinum. She had fever, gross hematuria, and malaise for three weeks after initiation of dapsone therapy. Five days after stopping dapsone treatment, she returned to the emergency clinic because of high fever, emesis, diarrhea, upper respiratory symptoms, and worsening of exanthematous eruptions. A diagnosis of DHS was made, and it improved with oral prednisone. We recommend that pediatric patients who are treated with dapsone need to be observed carefully for the development of DHS. (Ann Dermatol 23(S3) S290~S295, 2011)
Case Reports : Giant Piloleiomyoma of the Forehead
( Gun Wook Kim ),( Hyun Je Park ),( Hoonsoo Kim ),( Suhan Kim ),( Hyunchang Ko ),( Byungsoo Kim ),( Moonbum Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Cutaneous piloleiomyomas are benign smooth muscle tumors arising from the arrector pili muscles. Piloleiomyomas appear as firm dermal papules of skin color or with a reddish to brown surface, and are commonly located on the extremities. Histologically, these lesions are composed of interlacing bundles of smooth muscle cells in the reticular dermis. Our case presented with an unusually large nodule on the forehead that was accompanied by intermittent pain. Histological analysis was compatible with piloleiomyoma and the lesion showed haphazardly arranged bundles of smooth muscle in the dermis. We describe herein an interesting case of a giant piloleiomyoma occurring on the forehead. (Ann Dermatol 23(S2) S144~S146, 2011)
( Gun-wook Kim ),( Kihyuk Shin ),( Hyang-suk You ),( Hyun-ju Jin ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3
Background: Labial melanotic macules (LMMs) are benign pigmented lesions that usually take the shape of flat asymmetrical macules with tan-brown to black color and variable size. Whereas the dermoscopic features of other pigmented skin lesions have been relatively well described, little is known about LMMs. Objective: To describe the dermoscopic features and find typical and schematic dermoscopic patterns in LMMs. Methods: A retrospective dermoscopic study was conducted on 80 lesions with histopathologically proved LMMs. Results: We described and defined, for the first time to our knowledge, landscape painting patterns found in 65 of 80 melanotic lesions (81.3%), characterized by parallel lines or circle lines, overlapping vessels with background brown pigmentation. The background brown pigmentations were observed in 74 of 80 lesions (92.5%), the parallel lines in 62 (77.5%), the circle lines in 20 (25.0%), and overlapping vessels in 69 (86.3%). The structureless black pigmentations were only presented in 26 of 80 (32.5%). Conclusion: Dermoscopy can be useful for the clinical detection of LMMs, and “Landscape painting patterns” may represent a dermoscopic clue for the diagnosis of these lesions. (Ann Dermatol 30(3) 331∼334, 2018)
Narrowband UVB treatment of progressive macular hypomelanosis
Kim, Moon-Bum,Kim, Gun-Wook,Cho, Hyun-Ho,Park, Hyun-Je,Kim, Hoon-Soo,Kim, Su-Han,Kim, Byung-Soo,Ko, Hyun-Chang Elsevier 2012 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY - Vol.66 No.4
<P>Little information is available on effective treatments for progressive macular hypomelanosis (PMH). To our knowledge, only one case of narrowband ultraviolet B (NB-UVB) therapy as an efficient treatment for patients with PMH has been reported in the recent literature.</P>