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Du, Ze-Peng,Wu, Bing-Li,Xie, Jian-Jun,Lin, Xuan-Hao,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Wang, Shao-Hong,Shen, Jin-Hui,Li, En-Min,Xu, Li-Yan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13
Fascin-1 (FSCN1) is an actin-bundling protein that induces cell membrane protrusions, increases cell motility, and is overexpressed in various human epithelial cancers, including esophageal squamous cell carcinoma (ESCC). We analyzed various protein-protein interactions (PPI) of differentially-expressed genes (DEGs), in fascin knockdown ESCC cells, to explore the role of fascin overexpression. The node-degree distributions indicated these PPI sub-networks to be characterized as scale-free. Subcellular localization analysis revealed DEGs to interact with other proteins directly or indirectly, distributed in multiple layers of extracellular membrane-cytoskeleton/ cytoplasm-nucleus. The functional annotation map revealed hundreds of significant gene ontology (GO) terms, especially those associated with cytoskeleton organization of FSCN1. The Random Walk with Restart algorithm was applied to identify the prioritizations of these DEGs when considering their relationship with FSCN1. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile following fascin knockdown to future examine the roles and mechanisms of fascin action.
Du, Ze-Peng,Wu, Bing-Li,Wang, Shao-Hong,Shen, Jin-Hui,Lin, Xuan-Hao,Zheng, Chun-Peng,Wu, Zhi-Yong,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
NGAL (neutrophil gelatinase-associated lipocalin) is a novel cancer-related protein involves multiple functions in many cancers and other diseases. We previously overexpressed NGAL to analyze its role in esophageal squamous cell carcinoma (ESCC). In this study, a protein-protein interaction (PPI) was constructed and the shortest paths from NGAL to transcription factors in the network were analyzed. We found 28 shortest paths from NGAL to RELA, most of them obeying the principle of extracellular to cytoplasm, then nucleus. These shortest paths were also prioritized according to their normalized intensity from the microarray by the order of interaction cascades. A systems approach was developed in this study by linking differentially expressed genes with publicly available PPI data, Gene Ontology and subcellular localizaton for the integrated analyses. These shortest paths from NGAL to DEG transcription factors or other transcription factors in the PPI network provide important clues for future experimental identification of new pathways.
Isoflavanones from the Stem of Cassia siamea and Their Anti-tobacco Mosaic Virus Activities
Qiu-Fen Hu,De-Yun Niu,Bin Zhou,Yan-Qing Ye,Gang Du,Chun-Yang Meng,Xue-Mei Gao 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.10
Two new isoflavanones, (3R) 7,2',4'-trihydroxy-3'-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R) 7,2'-dihydroxy-3',4'-dimethoxy-5-methoxycarbonyl-isoflavanone (2), together with six known isoflavanones (3-8), were isolated from the stems of Cassia siamea. The structure of 1-8 was elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1, 2, 5-8 were evaluated for their antitobacco mosaic virus (Anti-TMV) activity. The results showed that compounds 1 and 6 showed potential anti- TMV activity with inhibition rates of 24.6% and 26.9%, respectively. Compounds 2, 5, 7, 8 also showed anti- TMV activity with inhibition rates in the range of 11.8-18.6%.
Amphiphilically modified chitosan copolymer for enhanced oil recovery in harsh reservoir condition
Wan-Fen Pu,Rui Liu,Qin Peng,Dai-Jun Du,Qi-Ning Zhao 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
A novel amphiphilically grafting natural chitosan copolymer (PAMCS) was prepared by using one stepwater-free radical polymerization strategy and the basic parameters for PAMCS were systematicallycharacterized. The rigid D-glucosamine unit, intermolecular association and hydrogen bondingsynergistically endowed PAMCS solution with rheological properties, super-high salt resistance andtemperature tolerance in harsh reservoir condition. PAMCS solution exhibited viscoelastic behaviorand formulated the unique displacement mechanism in comparison to that for partially hydrolyzedpolyacrylamide. Moreover, the mass concentration, injective rate and polymer solution slug related to oilrecovery efficiency for PAMCS were investigated from the economic point.
Dynamic Compressive Behavior of CTRC and ECC Layered Concrete under Impact Load
Aofei Guo,Fen Zhou,Yunxing Du,Rui Yan 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11
In this study, carbon textile reinforced concrete (CTRC) and engineered cementitious composites (ECC), together with steel fibers, were combined to fabricate two-layer concrete, called CTRC-ECC concrete. The dynamic compressive behavior of CTRC-ECC concrete was studied through the quasi-static compressive test and the impact test using a split Hopkinson pressure bar (SHPB). The effects of the thickness of CTRC, steel fibers, and impact face on the dynamic compressive strength, dynamic increase factor (DIF), strain at peak, and impact toughness of CTRC-ECC concrete were discussed. The results showed that as the thickness of CTRC increased, the dynamic compressive strength followed an increasing trend generally; the DIF decreased; and the strain at peak and the impact toughness increased firstly and then decreased. The addition of steel fibers to CTRC could increase the dynamic compressive strength significantly when the thickness of CTRC is less than 10 mm, improve the impact toughness slightly, but reduce the DIF significantly. In terms of the strain at peak, it firstly increased and then reduced and lastly did not change too much by steel fibers. The effect of impact face on the dynamic compressive strength, DIF, and impact toughness was not significant; however, when the CTRC face was subjected to impact load, the strain at peak could be slightly higher.
Study on Evenness Control for Tensionof Rapier Loom by Neural Network
Zheng Laijiu,Du Bing Jin,Wei Li Fen 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
This paper presents the use of neural network model (NNM) for air-jet loom's let-off process, which is used to model the uncertain parameters of this process. The adaptive model was used to estimate let-off tension recursively and is incorporated in predictive control strategies. Control tests showed excellent behavior following different set point and variations, such as diameter of weaver's beam, air stream, density of warp and weft, type of textile, etc. An optimum steady state scheme in keeping evenness of let-off tension of loom has been realized. After adopting the method, it improves production efficiency and product quality obviously, its flaw amount also falls 80%.
Isoflavanones from the Stem of Cassia siamea and Their Anti-tobacco Mosaic Virus Activities
Hu, Qiu-Fen,Niu, De-Yun,Zhou, Bin,Ye, Yan-Qing,Du, Gang,Meng, Chun-Yang,Gao, Xue-Mei Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10
Two new isoflavanones, (3R) 7,2',4'-trihydroxy-3'-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R) 7,2'-dihydroxy-3',4'-dimethoxy-5-methoxycarbonyl-isoflavanone (2), together with six known isoflavanones (3-8), were isolated from the stems of Cassia siamea. The structure of 1-8 was elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1, 2, 5-8 were evaluated for their anti-tobacco mosaic virus (Anti-TMV) activity. The results showed that compounds 1 and 6 showed potential anti-TMV activity with inhibition rates of 24.6% and 26.9%, respectively. Compounds 2, 5, 7, 8 also showed anti-TMV activity with inhibition rates in the range of 11.8-18.6%.
Zhao Youqun,Du Xianbin,Lin Fen,Wang Qiang,Fu Hongxun 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.7
To eliminate the potential risk factors of the conventional inflatable tire, a creative non-pneumatic tire named “ME-wheel” was developed. Based on the analysis of the bearing characteristics, four types of ME-wheel with varying hinge structures and distributions were designed. The static stiffness characteristics of these four ME-wheels were investigated by numerical simulations and experiments. The hyperelasticity and incompressibility of the rubber material were described by the Mooney–Rivlin model, and the multilayer rubber-cord composites were modeled by the rebar layer. The nonlinear finite element model of the ME-wheel, which included nonlinear property of the material, contact condition, and anisotropy of rubber-cord composites, was validated by the load characteristic test. Stiffness characteristic tests of these four types of ME-wheel and a pneumatic tire, including vertical, longitudinal, lateral, and torsional stiffness, were carried out using a low speed flatbed test bench. A sufficient comparison and analysis were made between the experimental data and simulation data. The research results provided some theoretical and technical verification on the performance and structural optimization of the ME-wheel.