LT, Others : PE-133 ; A case of hepatic hemangioma appearing atypical finding confirmed by dynamic MRI in patients with high risk of hepatocellular carcinoma

( Dong Won Park1 ),( Soo Hyung Ryu1 ),( Myung Ki Oh ),( Seong Yeon Jeong ),( Kyeong Sam Ok ),( Jae Chan Shim ),( Jin Nam Kim ),( You Sun Kim ),( Jeong Seop Moon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Hemangioma is the most common benign hepatic tumor. Many hepatic hemangiomas tend to be found incidentally, but should be differentiated from malignant tumors. We report an interesting case of hepatic hemangioma in patient who has high risks of hepatocellular carcinoma. Case: A 52-year-old woman, who was a chronic alcoholic abuser and hepatitis C virus carrier with no treatment experience, was admitted due to diarrhea. The patient had suffered from intermittent abdominal pain in the right subcostal area for recent 3 months. Also the patient had easy bruising and frequent epistaxis. She had used oral contraceptives for almost 20 years. Systolic blood pressure was 160 mmHg and diastolic blood pressure was 80 mmHg. Body temperature was normal. Physical examination revealed icteric sclerae and tenderness in right upper quadrant of the abdomen. Laboratory study showed platelet count of 31,000/ul, AST/ALT of 302/127 IU/L, and total bilirubin of 2.7 mg/dl. 3-phased contrast-enhanced abdominal computed tomography (CT) revealed a 4 cm × 4 cm sized hepatic mass involving both segment 5 and 6. Abdominal CT finding suggested hepatic hemangioma, however, typical finding of hemagioma was unclear, therefore, could not rule out the malignancy. Since she had risk factors for hepatocellular carcinoma, abdominal ultrasonography was performed for further evaluation. But abdominal ultrasonography also showed atypical finding. The confirmative diagnosis could be done by dynamic magnetic resonance imaging (MRI) using primovist®, which is an innovative liver cell-specific contrast medium. Dynamic MRI presented peripheral globular enhancement and a centripetal fill-in pattern, confirmatory findings of hepatic hemangioma, on the delayed image. The patient got relief from abdominal pain and diarrhea during admission, now is being followed-up at a general out-patient clinics. Conclusions: Hemangiomas with atypical abdominal CT and ultrasonographic findings in patients with high risks of hepatocellular carcinoma can be easily characterized with primovist-enhanced dynamic MRI.

하대정맥 후요관에 발생한 다발성 요로 상피세포암 1례

나길주,정동원,권동득,오봉렬,류수방,박양일 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.5

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Culture of Karyoplast and Cytoplast Complexes in High Osmolarity after Fusion Improve In Vitro Development of Porcine Nuclear Transfer Embryos

Gi-Sun 1m,In-Sun Hwang,Dong-Hoon Kim,Byoung-Chul Yang,Se-Woong Kim,Hyo-Suk Park,Jin-Sung Seo,Bo-Suk Yang,Won-Kyong Chang 한국동물생명공학회(구 한국동물번식학회) 2004 Reproductive & Developmental Biology(Supplement) Vol.28 No.2s

Apoptosis of Parthenogenetic Preimplantation Porcine Embryos Activated and Cultured in Different Condition

h-Sun Hwang,Gi-Sun 1m,Dong-Hoon Kim,Byoung-Chul Yang,Hyo-Suk Park,se-Woong Kim,Jin-Sung Seo,Bo-Suk Yang,Won-Kyong Chang 한국동물생명공학회(구 한국동물번식학회) 2004 Reproductive & Developmental Biology(Supplement) Vol.28 No.2s

주성분분석과 지구통계법을 이용한 제주도 지하수의 수리지화학 특성 연구

고경석(Kyung-Seok Ko),김용제(Yongje Kim),고동찬(Dong-Chan Koh),이광식,이승구,강철희(Cheol-Hee Kang),성현정(Hyun-Jeong Seong 1),박원배(Won-Bae Park) 대한자원환경지질학회 2005 자원환경지질 Vol.38 No.4

본 연구는 다변량 통계분석을 이용하여 수리지화학적 특성을 분석하고, 주성분 분석을 통해 얻어진 변수를 설명하는 수리지화학적 과정에 대한 해석, 그리고 각 성분과 주성분을 이용한 공간정보에 대하여 지구통계기법을 적용하여 연구지역 지하수의 유동 및 순환 과정을 해석하고자 하였다. 제주도 지하수의 수질에 가장 많이 영향을 미치는 성분은 Cl 과 NO 3 이었으며, 특히 농업활동에 의해 증가되는 NO 3 는 지하수 성분 중 가장 큰 변동을 보여주었다. 다변량 통계분석법인 주성분 분석(PCA)에 의한 수리지화학적 특성 분석 결과, 초기 3 개의 주성분은 전체 분산의 73.9% 를 설명하였다. 주성분 1 은 용존 이온의 증가를 나타내며, 주성분 2 는 탄산염 광물의 용해와 질산염 오염의 영향, 주성분 3 은 양이온 교환반응과 규산염광물의 용해과정을 지시한다. 실험적 반베리오그램 유형 분석 결과 지하수 성분은 크게두 그룹으로 분류되며 각각의 그룹에는 EC, Cl, Na, NO 3 와 HCO 3 , SiO 2 , Ca, Sr 이 속한다. 지하수 성분의 공간분포 특징을 조사한 결과, 전기전도도(EC), Cl, Na 는 해수의 영향을 받는 해안가로 갈수록 증가하는 경향을 보여주며, NO 3 는 농경지의 분포와 밀접한 상관관계를 가진다. 이들 성분은 또한 지형과도 상관성을 가지며 이는 지하수 함양과의 관련성을 나타낸다. 요인 크리깅 수행 결과 PC1 은 Cl, Na, EC 의 공간분포와는 다른 양상을 보여주는데 이는 pH, Ca, Sr, HCO 3 가 PC1 에 미치는 영향 때문인 것으로 분석되었다. 서부지역에서는 PC2 의 이상대가 길게 나타나며 이는 탄산염 광물의 용해와 관련이 있는 것으로 사료된다. 이상의 결과로부터 연구지역 지하수에 대한 다변량 통계분석및 지구통계 분석 기법의 적용은 수질에 대한 복합적 정보의 정량화와 공간 특성을 해석하는데 사용될 수 있다. The purpose of the study is to analyze the hydrogeochemical characteristics by multivariate statistical method, to interpret the hydrogeochemical processes for the new variables calculated from principal components analysis (PCA), and to infer the groundwater flow and circulation mechanism by applying the geostatistical methods for each element and principal component. Chloride and nitrate are the most influencing components for groundwater quality, and the contents of NO 3 increased by the input of agricultural activities show the largest variation. The results of PCA, a multivariate statistical method, show that the first three principal components explain 73.9% of the total variance. PC1 indicates the increase of dissolved ions, PC2 is related with the dissolution of carbonate minerals and nitrate contamination, and PC3 shows the effect of cation exchange process and silicate mineral dissolution. From the results of experimental semivariogram, the components of groundwater are divided into two groups: one group includes electrical conductivity (EC), Cl, Na, and NO 3 , and the other includes HCO 3 , SiO 2 , Ca, and Sr. The results for spatial distribution of groundwater components showed that EC, Cl, and Na increased with approaching the coastal line and nitrate has close relationship with the presence of agricultural land. These components are also correlated with the topographic features reflecting the groundwater recharge effect. The kriging analysis by using principal components shows that PC1 has the different spatial distribution of Cl, Na, and EC, possibly due to the influence of pH, Ca, Sr, and HCO 3 for PC1. It was considered that the linear anomaly zone of PC2 in western area was caused by the dissolution of carbonate mineral. Consequently, the application of multivariate and geostatistical methods for groundwater in the study area is very useful for determining the quantitative analysis of water quality data and the characteristics of spatial distribution.

특별기고논문 : 감리사례 ; 도산모형과 비재무적요인을 이용한 영화투자기업의 감사실패사례연구

박성종(제1저자) ( Sung Jong Park ),김동원(교신저자) ( Dong Won Kim ),정준희(공동저자) ( Joon Hei Cheung ) 한국회계학회 2015 회계저널 Vol.24 No.3

본 사례는 증권선물위원회의 감리결과로 나타난 영화투자업을 영위하는 페일필름의 회계 부정과 파산사례를 살펴보는 것을 목적으로 한다. 이를 위해, 사업보고서의 비재무사항과 재무사항을 통해 페일필름의 분식회계 위험과 징후를 살펴보고, 파산위험에 대해 알아본다. 다음으로, 페일필름의 구체적인 회계부정의 방법과 항목을 살펴본다. 나아가 감사인의 감사실패 사항을 분석함으로써, 감사인의 책임과 윤리의식에 대해 논한다. 본 연구는 재무제표 작성자와 감사인뿐만 아니라 투자자 관점을 함께 고려하여 감리사례를 분석하고자 하였다. 이를 위해, 사업보고서에 나타난 비재무사항 10개를 선정하여 비재무사항이 감사위험에 미치는 영향을 분석하고, Altman Z-SCORE를 통해 파산위험과 감사위험에 대해 살펴보았다. 끝으로 감사인의 윤리의식에 대해 논하였다. 본 사례를 통해, 회계부정, 파산위험 및 사업보고서의 분석을 아울러 배울 수 있으며, 감사인의 책임과 윤리의식에 대해 학습할 수 있을 것으로 기대한다. This study investigates the method, item and bankruptcy risk of unjust accounting through the case of window dressing accounting of "Fail Film" found under the system of supervision. Further, it analyzes the sign of unjust accounting through non financial matters of business report of "Fail Film". In addition, we invest each issues regarding the violation of the accounting principle such as, advance payments, investments in stocks accounted for under the equity method and contingent liability. Although "Fail Film" carried on publication and advertisement service business, its business type actually changed when major stockholders changed in December, 2005 and entertainment business like film investment and distribution business became main business since 2006. Even though the company did not change auditor since establishment (even after it was listed), it first changed auditor after changing major stockholders. Before change, the auditors expressed standard opinion on their final audit report, but indicated 13 items as specific matters. Since specifying specific matters in 13 items was very unusual situation, the company appeared abnormal only with such number of specific matters instead of seriousness of the individual item of specific matters. Although the new auditor fully recognized such abnormal situation, he decided to take audit job and concluded audit agreement. The new auditor failed to reflect the error of diminutive appropriation of sales cost in the audit opinion, failed to find the error of excessively appropriated advanced payment, because the auditor as an expert failed to fully audit advanced payment which occupied 28% of total asset of the company. Further, the auditor failed to find the fact that many notes and checks were provided for mortgage. The "Fail Film" has many non financial information about manager``s fraud and earnings management. The "Fail Film" does not have audit committee, financial experts in the audit committee, labor union, foreign investors and nominating committee that associated with lower levels of earnings management and accounting irregularities. In addition, "Fail Film" changechief executive officer and major stockholders, corporate name in 2005. The information is meaningful in that it can provide auditor with warning signals for predicting accounting fraud. The auditor of "Fail Film" failed in audit as stated above, although he understood the individual items of specific matters and their number written in the audit opinion of previous auditor as well as non financial information, and financial information of "Fail Film". This fact implies that he was quite problematic in the ethical level of auditor and expertise, the basic requirement of auditor who audits accounting. Through the case of failed accounting of auditor for "Fail Film", we are to check the method used for unjust accounting of the company and the problems in audit procedure of auditor in the process of accounting audit. Therefore, we suggest that auditor and regulator need to use various non financial information and bankruptcy forecasting models such as Altman``s Z-score for finding accounting fraud or earnings management. We hope that researcher find other non information that associated with higher levels of accounting fraud. This study is meaningful in that it considers not only the viewpoint of preparer of financial statements and auditor but also that of investor. For instance, it presented the significant items of non financial matters indicted on the business report, thereby providing merit to learn the analysis of unjust accounting, bankruptcy risk and business report. It is expected that the participants of capital market, its researchers and students can learn the responsibility and ethical sense of auditor with knowledge in audit procedure.

연구보문 : 식물환경 ; 폐가축사체의 농업적 재활용을 위한 가축사체 액상부산물의 액비화 조건 구명

서영진 ( Young Jin Seo ),서동철 ( Dong Cheol Seo ),강세원 ( Se Won Kang ),이상규 ( Sang Gyu Lee ),박주왕 ( Ju Wang Park ),최익원 ( Ik Won Choi ),성환후 ( Hwan Hoo Sung ),강석진 ( Seog Jin Kang ),조주식 ( Ju Sik Cho1 ) 한국환경농학회 2013 한국환경농학회지 Vol.32 No.4

가축사체 액상부산물을 이용하여 액비의 최적조건(미생물, pH, 미생물 주입량)을 조사하였고, 이들 최적 조건하에서 112일간 부숙하여 액비의 품질을 평가하였다. 가축사체 액상 부산물 액비 부숙시 최적 LP 미생물의 주입량은 0.5 mL/100mL이었으며, pH는 7 조건에서 각각 50점으로 완숙판정을 받았다. 최적조건하에서 112일 동안 부숙시킨 액비의 부숙도 는 부숙 후 28일에 50점을 받아 완숙판정을 받았으며, 부숙기 간이 길어짐에 따라 부숙 56일에는 온도가 60℃를 넘어 최고 점인 55점을 받았고, 이후 온도가 조금씩 낮아져 부숙 후 112 일에는 실온조건에 이르렀다. 완숙된 가축사체 액상부산물 액 비의 품질을 평가해본 결과, 최적조건하에서 부숙시킨 액비의 경우에는 T-N, P2O5 및 K2O의 함량이 28일에 가장 높았으며, 시간이 경과함에 따라 약간 감소하는 경향이었다. 또한, 유해성분(As, Cd, Cu, Cr, Hg, Ni, Pb 및 Zn)의 함량은 28일, 56일 및 112일 부숙시킨 액비에서 모두 비료공정규격 기 준치에 적합하였다. 이상의 결과를 미루어 볼 때 가축사체 액상부산물을 농업적 재활용을 위한 액비화 조건은 pH 7조건 에서 LP 미생물을 0.5 mL/100 mL 주입한 경우이다. 하지 만 본 연구에서 비교된 가축분뇨 발효액은 공시재료(가축사체)가 상이하여 향후 가축사체를 이용한 액비의 부숙도 기준이 개선되어야 할 것으로 판단된다. BACKGROUND: Globally, concern about emerging infectious diseases of livestock is growing. For the disposal of the animal carcass, it is necessary to recycle the carcass into an agriculturally usable product. The objective of this study was to investigate the composting conditions of liquid by-product obtained from degradation of animal carcass. METHODS AND RESULTS: Optimum conditions of liquid fertilizer were investigated using different microorganisms, pHs, and volumes of microorganisms (Lactobacillus rhamnosus + Pichia deserticola). Based on the results from the optimum conditions, compost maturity and quality of liquid fertilizer were evaluated for 112 days. The compost maturity of liquid fertilizer were higher in the order of LP(Lactobacillus rhamnosus + Pichia deserticola) > BC(Bacillus cereus) > BS (Bacillus subtilis). The optimum condition under different volumes of LP was injection of 0.5 mL/100 mL. The compost maturity under different pHs were higher in the order of pH 7 > 5 ≥ 9 ÷ 11. The liquid by-product at 56 days after composting was completely decomposed. The concentrations of T-N, T-P and K2O in liquid fertilizer at 56 days were 0.94, 0.17 and 3.78%, respectively, and the sum of those concentrations was 4.89%. CONCLUSION(S): Liquid fertilizer of by-product using pig carcass was decomposed with optimum conditions(LP, pH 7, injection of 0.5 mL/100 mL) in 56 days after composting, and was suitable for official standard of commercial fertilizer.

HCV, Alcoholic : PE-096 ; Clinical and histopathological features of acute onset autoimmune hepatitis

( Min Young Rim ),( Soo Yong Park ),( In Ku Yo ),( Min Su Ha ),( Ju Seung Kim ),( Ju Won Lee ),( Young Kul Jung ),( Dong Hae Chung ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Joo Choi ),( Ju Hyun Kim1 ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Autoimmune hepatitis (AIH) is a progressive inflammatory liver disease of unknown etiology that is reported to be a consequence of aberrant autoreactivity. Several studies which reported the acute presentation of AIH have different clinical course and histologic features. In this study, we compared acute presentation of AIH and chronic presentation of AIH. Methods: We retrospectively reviewed the medical records of patients with autoimmune hepatitis from January 2003 to June 2011 at Gachon University, Gil Hospital. A total of 29 patients were enrolled, 7 patients were diagnosed with acute presentation of AIH. Results: There was no difference between two group in age, gender, and score system of AIH. Patients with acute presentation had higher serum levels of total bilirubin, lower serum levels of albumin in clinical feature (p<0.05), and higher frequency of zone 3 necrosis in histologic feature. The cumulative incidental rate of the normalization of serum AST and ALT levels with prednisolone treatment was similar between patients with acute presentation and chronic presentation in clinical course. Conclusions: Higher AST, ALT and, bilirubin were clinical specific feature, and zone 3 necrosis is a histological characteristic of autoimmune hepatitis with acute presentation.

흰쥐의 전층피부손상에서 온청음(溫淸飮)이 신생혈관형성에 미치는 영향

김범회,이해웅,손낙원,박동일,Kim, Bum-Hoi,Lee, Hae-Woong,Sohn, Nak-Won,Park, Dong-Il1 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.1

The wound healing process can be categorized as follows : inflammation, fibroplasia, neovascularization, collagen deposition, epithelialization, and wound contraction. During the healing process, various growth factors are secreted to accelerate wound healing. Previous studies have demonstrated that endogenous growth factors, such as vascular endothelial growth factor(VEGF) are the important regulatory polypeptides for coordinating the healing process. They are released from macrophages, fibroblasts, and keratinocytes at the site of injury and participate in the regulation of reepithelization, granulation tissue formation, collagen synthesis and neovascularization. Onchung-Um has been used clinically to treat various skin diseases. In addition, Onchung-Um has been also used for congestive inflammations. In the present study, we evaluated the effects of Onchung-Um on wound healing process and wound size reduction in rats. Full-thickness skin wounds ($15mm\;{\times}\;15mm$) were created on the back of rats. Rats were then divided into 2 groups : The Onchung-Um treated group that was orally administered with a dose of 193.9mg/100g of Onchung-Um extract per day for 15 days and Control group without Onchung-Um administration. Moreover, the histological changes and VEGF immunoexpressions of two groups were estimated. In results, wound closures were significantly accelerated by oral administration of Onchung-Um extract. Furthermore, in Onchung-Um treated group, there were significant increases in fibroblast migration, epithelialization compared with the Control group. VEGF expressions were also increased in Onchung-Um treated group. This study has therefore demonstrated the Onchung-Um can significantly improve the quality of wound healing and scar formation and the oral administration of Onchung-Um extract may increase early tissue angiogenesis in the incisional wound of an experimental animal model.