Diagnosis of Diabetic Foot Grade Using Deeplens Based on Artificial Intelligence

Boyoon Choi 대한외과학회 2021 대한외과학회 학술대회 초록집 Vol.2021 No.11

Population pharmacokinetics and pharmacodynamics of busulfan with<i>GSTA1</i>polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation

Choi, Boyoon,Kim, Myeong Gyu,Han, Nayoung,Kim, Therasa,Ji, Eunhee,Park, Seonyang,Kim, In-Wha,Oh, Jung Mi Future Medicine Ltd. 2015 Pharmacogenomics Vol.16 No.14

<P>A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation.</P>

Development and Degeneration of Retinal Ganglion Cell Axons in Xenopus tropicalis

Boyoon Choi,Hyeyoung Kim,Jungim Jang,Sihyeon Park,Hosung Jung 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.11

Neurons make long-distance connections via their axons, and the accuracy and stability of these connections are crucial for brain function. Research using various animal models showed that the molecular and cellular mechanisms underlying the assembly and maintenance of neuronal circuitry are highly conserved in vertebrates. Therefore, to gain a deeper understanding of brain development and maintenance, an efficient vertebrate model is required, where the axons of a defined neuronal cell type can be genetically manipulated and selectively visualized in vivo. Placental mammals pose an experimental challenge, as time-consuming breeding of genetically modified animals is required due to their in utero development. Xenopus laevis, the most commonly used amphibian model, offers comparative advantages, since their embryos ex utero during which embryological manipulations can be performed. However, the tetraploidy of the X. laevis genome makes them not ideal for genetic studies. Here, we use Xenopus tropicalis, a diploid amphibian species, to visualize axonal pathfinding and degeneration of a single central nervous system neuronal cell type, the retinal ganglion cell (RGC). First, we show that RGC axons follow the developmental trajectory previously described in X. laevis with a slightly different timeline. Second, we demonstrate that co-electroporation of DNA and/or oligonucleotides enables the visualization of gene function-altered RGC axons in an intact brain. Finally, using this method, we show that the axon-autonomous, Sarm1-dependent axon destruction program operates in X. tropicalis. Taken together, the present study demonstrates that the visual system of X. tropicalis is a highly efficient model to identify new molecular mechanisms underlying axon guidance and survival.

Fever in Trauma Patients without Brain Injury

Boyoon Choi,Kiyoung Sung,조진범 대한외상중환자외과학회 2021 Journal of Acute Care Surgery Vol.11 No.1

Purpose: Distinguishing a fever caused by infection from the necessary febrile response in injuredpatients is difficult, because trauma patients often have concomitant obvious infectious origins. Intraumatic brain injury, early fever might be associated with worse clinical outcomes; however, fewreports on trauma patients without brain injury are available. Methods: In this retrospective observational study, consecutive trauma patients without braininjury who were admitted to the surgical intensive care unit during a 3 year period were included. The surgical and clinical outcomes were compared according to body temperature. Locally weightedscatterplot smoothing was used to identify the relationship between body temperature and injuryseverity. Results: A total of 111 patients were included. Body temperature increased as the injury severityscore increased up to 47.717, above which it decreased. Mortality was high in hypothermicpatients (72.7%; p < 0.001); however, few differences were observed between normothermic andhyperthermic patients (3.5% and 2.4%, respectively). The nonsurvivors had lower body temperatureson the 1st and 2nd days after admission (36 ˚C and 36.9 ˚C) compared with the survivors (37.3 ˚C and37.7 ˚C; p < 0.001 and p = 0.006). In severely injured patients, low levels of inflammatory biomarkersand low body temperature were correlated with mortality. Conclusions: Fever in trauma patients without brain injury is correlated with injury severity but notwith prognosis. Hypothermia on the 1st and 2nd days after admission was significantly correlatedwith mortality. In severely injured patients, a decreased inflammatory response might play a certainrole in promoting a high mortality rate.

확진보다 무서운 낙인? 유행시기별 코로나19 보도 헤드라인에 나타난 낙인 양상 분석

오준혁(JunHyeok Oh),이보윤(BoYoon Lee),최미연(MiYeon Choi),최윤형(YoonHyeung Choi) 한국광고홍보학회 2023 한국광고홍보학보 Vol.25 No.1

한국의 사회동향 조사(2020)에 따르면, 대다수 국민은 코로나19 확진보다 코로나 낙인에 대한 두려움이 더 큰 것으로 조사됐다. 본 연구는 이러한 감염병 낙인 문제에 초점을 두고 코로나19 발생 첫1년(2019년 12월 31일~2021년 1월 31일)의 기간 동안 주요 일간지 헤드라인에 나타난 코로나19 보도를 내용 분석하였다. 해당 시기 주요 사건, 방역 정책, 정부 메시지, 감염자 및 사망자 수 등 맥락을 포함한 5개의 유행시기로 나누어 분석한 결과, 전체 분석 헤드라인 중 66.5%에서 낙인 표현이 사용된 것으로 나타났고 낙인 표현은 전 유행시기에 걸쳐 꾸준히 60%이상의 높은 빈도를 보였다. 가장 빈번히 사용된 낙인 요소는 공포감유발(53.6%), 라벨링(28.9%), 책임귀인(16.2%), 표시(1.3%) 순으로 나타났으며 낙인 표현의 주된 대상 및 내용은 유행시기별 주요 사건에 영향을 받은 것으로 나타났다. 하지만, 전체적인 방역 정책의 변화, 정부 메시지 등 맥락을 고려하지 않은 채 특정 집단에게 코로나19 관련 낙인 표현이 집중된 패턴이(예: 신천지, 이태원 관련, 교회) 확인되기도 했다. 본 연구는 감염병 보도에서 반복되는 낙인요소를 비교적 긴 스펙트럼으로 맥락을 고려하여 분석했다는 점, 그리고 법적 · 자율적 규제의 필요성을 환기했다는 점에서 의의가 있다. According to the Korean Social trends(2020), it was seen that majority of people feared the stigma of getting infected with COVID-19 more than the fear of being infected. This study analyzes the headlines of news reports of major daily newspapers during the first year of outbreak. Results showed that 66.5% of the healines analyzed in this study used expressions associated with stigma, and this pattern appeared around 60% through the entire epidemic period. Most frequently used stigma factors were Peril(53.6%), Labeling(28.9%), Responsibility(16.2%), and Mark(1.3%). In particular, the patterns of stigmatization related to COVID-19 were concentrated on specific groups(e.g., Shincheonji, Itaewon, churches) without considering the contexts such as changes in the overall quarantine policy and government’s messages. Practical and policy implications are discussed.

효율적인 의약품 평가를 위한 약물계량학 분석법 도입의 전략 방안

( Sang Min Lee ),( Boyoon Choi ),( Hwi Yeol Yun ),( Da Hae Jun ),( Myung Gou Kim ),( Ji Hye Ha ),( Young Hoon Kim ),( Eun Hee Ji ),( Won Ku Kang ),( Na Young Han ),( Wan Gyoon Shin ),( Jung Mi Oh ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Over the past few decades, drug regulatory agencies in advanced countries have been emphasizing pharmacomctrics as a tool for an effective and efficient drug evaluation. Despite this international movement, the value of pharmacometrics is still poorly recognized by the Korean drug evaluation system. This study aimed to analyze the current state of utiliza-tion of pharmacometrics by foreign drug regulatory agencies and develop a road map to guide the implementation phar- macometrics into the Krean drug evaluation system. MEDLINE and foreign drug regulatory agency database were extensively searched to obtain scientific research articles, guidance, regulations and pharmacometric review reports on foreign pharmacometric drug evaluation system. A systematic roadmap comprised of 3 stages to implement pharmaco-metrics in Lorean drug evaluation system was formulated after analyzing the collected data in tune with the current evaluation system. Pharmacometrics is an urgently required tool to achieve an efficient drug evaluation and review in Korea. The road map developed by this study is expected to aid in setting up a policy to implement and utilize phar-macometrics in Korea.

중등 영어교사 양성 과정에 관한 연구

장경숙(Chang Kyungsuk),정규태(Jung Kyutae),최보윤(Choi Boyoon) 팬코리아영어교육학회(구 영남영어교육학회) 2008 영어교육연구 Vol.20 No.2

  This research addresses two key issues surrounding the curriculum for training pre-service secondary English teachers: ‘What information, skills or knowledge are to be taught or learnt?’ and ‘How are they to be conveyed, trained, or taught?’ It aims to investigate beliefs and attitudes student teachers and trainers hold about the current secondary English teacher training curriculum, medium of instruction, microteaching and field experience. In the present survey parallel questionnaires were designed and answered by 48 professors and 426 students from English education department of 17 universities. According to the findings, teacher and student groups agree that teaching practice has been neglected in the current curriculum. The results also reveal that both groups believe that students can benefit from teaching subjects in English, but they do not agree that all the subjects need to be taught in the target language. It is found that there is a gap between teacher feedback and students’ need for supervision. It is suggested that the findings of the survey provide training course designers and policy makers with implications for making decisions on initial English teacher education.

멘토링을 통한 중등영어 초임교사 수업 전문성 발달 지원에 관한 연구

장경숙 ( Kyungsuk Chang ),김민겸 ( Minkyum Kim ),최보윤 ( Boyoon Choi ) 한국중등영어교육학회 2012 중등영어교육 Vol.5 No.2

This study investigated how secondary English novice teachers`` continuing professional development was pursued through mentoring. Three novice teachers took part as mentee, and 5 experienced teachers and overseas specialists were involved as mentors. Data was gathered through video-taped lessons, observation, interview, and research journals. The data collected from different sources was categorized according to their saliency, frequency and to those recurring patterns found within. The findings revealed that mentoring was given with focus on areas such as the use of mother tongue, learning strategies, teaching objectives, discipline, learning atmosphere, error correction, learning styles, and language skill integration. It was also found that the mentors with different background showed different ways of providing consulting on the novice teachers`` classes observed. Suggestions were made for the effective implementation of novice teacher support program and continuing professional development.

초ㆍ중등 영어 교과 수업컨설팅에 대한 인식 연구

장경숙(Chang, Kyungsuk),민병수(Min, Byungsoo),최보윤(Choi, Boyoon) 한국외국어교육학회 2013 Foreign languages education Vol.20 No.4

The present study aims to seek ways of activating teaching consulting by investigating how primary and secondary English teachers perceive consulting. A survey was conducted to investigate the current state of English teaching consulting at schools and to identify needs to be met for effective consulting. 157 primary and 107 secondary English teachers took part in the survey using a questionnaire. The major findings from the data analysis are summarized as follows: (1) teaching consulting is not widely accepted as significant in professional development yet, and teaching consulting is not likely to be done voluntarily; (2) there is lack of professional consultants; (3) the administration process involved in consulting needs to be truncated and made simple; (4) the evaluation of consulting needs to be fed back in improving teaching and professional learning; and (5) teachers' voluntary involvement in consulting and cooperative professional development are considered to be important to activate and sustain consulting. Some measures are suggested to vitalize consulting in English teaching at schools and directions for future research are discussed.

ABCB1 C3435T Genetic Polymorphism on Population Pharmacokinetics of Methotrexate After Hematopoietic Stem Cell Transplantation in Korean Patients: A Prospective Analysis

Kim, In-Wha,Yun, Hwi-yeol,Choi, Boyoon,Han, Nayoung,Park, Seon-Yang,Lee, Eun Sook,Oh, Jung Mi Elsevier 2012 Clinical therapeutics Vol.34 No.8