농어촌 지역의 한방의료 이용 실태에 관한 조사 : 전남 신안군 장산면을 중심으로

宋峰根,黃忠演,文錫哉 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

The prevalence of disease is affected by cultural factors. Changing cultural and social pattern may modify patterns of disease. Today majority of labor force in rural community is elderly population with a concomitant increase in woman. We investigated prevalence of problems in rural population utilizing oriental medical clinic in Changsan-myon, Shinan-gun, Chunnam. The majority of patients in this area were female and in the 40 to 60s. Muscoskeletal problems had the highest incidence. Low back pain was leading complaints in the muscoskeletal problems and knee pain was the most common complaints in the digestive problems, headache in the neurologic problems. cough in the respiratory problems, hypertension in the circulatory problems, ear problems in the sense organ problems, pruritys in the dermatologic problems, leukorrhea and postmenopausal syndrome in the gynecologic problems, and dysuria and enuresis in the urinary problems. These results suggest that oriental medical physicians have attention to health care and management of the expanding population of elderly and female patients with high incidence of muscoskeietal problems in the rural community.

Chronic Ethanol Consumption Inhibits Glucokinase Transcriptional Activity by <i>Atf3</i> and Triggers Metabolic Syndrome <i>in Vivo</i>

Kim, Ji Yeon,Hwang, Joo-Yeon,Lee, Dae Yeon,Song, Eun Hyun,Park, Keon Jae,Kim, Gyu Hee,Jeong, Eun Ae,Lee, Yoo Jeong,Go, Min Jin,Kim, Dae Jin,Lee, Seong Su,Kim, Bong-Jo,Song, Jihyun,Roh, Gu Seob,Gao, Bi American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.39

<▼1><P><B>Background:</B> Chronic ethanol consumption induces pancreatic β-cell dysfunction and metabolic syndrome.</P><P><B>Results:</B> Ethanol-induced Atf3 inhibits glucokinase transcriptional activity through direct binding or Atf3/Pdx-1/Hdac1 axis on glucokinase promoter.</P><P><B>Conclusion:</B> ATf3 fosters β-cell dysfunction via <I>Gck</I> down-regulation and triggers T2D, which is ameliorated by <I>in vivo Atf3</I> silencing.</P><P><B>Significance:</B> The presented data uncover a new role for Atf3 as a potential therapeutic target in treating type 2 diabetes.</P></▼1><▼2><P>Chronic ethanol consumption induces pancreatic β-cell dysfunction through glucokinase (Gck) nitration and down-regulation, leading to impaired glucose tolerance and insulin resistance, but the underlying mechanism remains largely unknown. Here, we demonstrate that <I>Gck</I> gene expression and promoter activity in pancreatic β-cells were suppressed by chronic ethanol exposure <I>in vivo</I> and <I>in vitro</I>, whereas expression of activating transcription factor 3 (Atf3) and its binding to the putative Atf/Creb site (from −287 to −158 bp) on the <I>Gck</I> promoter were up-regulated. Furthermore, <I>in vitro</I> ethanol-induced Atf3 inhibited the positive effect of Pdx-1 on <I>Gck</I> transcriptional regulation, enhanced recruitment of Hdac1/2 and histone H3 deacetylation, and subsequently augmented the interaction of Hdac1/Pdx-1 on the <I>Gck</I> promoter, which were diminished by <I>Atf3</I> siRNA. <I>In vivo Atf3</I>-silencing reversed ethanol-mediated <I>Gck</I> down-regulation and β-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin resistance. Together, we identified that ethanol-induced <I>Atf3</I> fosters β-cell dysfunction via <I>Gck</I> down-regulation and that its loss ameliorates metabolic syndrome and could be a potential therapeutic target in treating type 2 diabetes. The <I>Atf3</I> gene is associated with the induction of type 2 diabetes and alcohol consumption-induced metabolic impairment and thus may be the major negative regulator for glucose homeostasis.</P></▼2>

Effects of active drinking practices on fluid consumption and sweat rate while exercising in a hot environment

( Youn Sun Son ),( Bong Yeon Hwang ),( Dae Taek Lee ),( Yoon Jung Bae ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.2

Youn Sun Son, Bong Yeon Hwang, Dae Taek Lee and Yoon Jung Bae. Effects of active drinking practices on fluid consumptionand sweat rate while exercising in a hot environment. JENB., Vol. 18, No. 2, pp.215-223, 2014 [Purpose]To examine the effectsof active drinking practices on fluid consumption and sweat rate while exercising in a hot environment. [Methods]Nine mencompleted two experiments. Each consisted of 3 phases: pre-testing (pre), training period, and post-testing (post). During testing,the subjects ran on a treadmill at a moderate intensity for 90 min at 39 ± 1℃ followed by a 3-h recovery. They drank ad libitum. During training, they ran for 90 min for 7 days while either drinking actively (AH, 150% of weight loss) or passively (PH,50% of weight loss). [Results]The actual volume consumed in training was three times greater during AH than during PH. Inpost during AH, the volume of drinking was two times greater than pre (1592 ± 953 and 855 ± 551 mL, respectively; p < 0.05). No difference in volume consumption during PH between pre and post was found. The sweat loss during exercise was greaterin post (1377 ± 956 mL) than in pre (558 ± 642 mL) during AH (p < 0.05), but not during PH. Rectal temperature and heartrate decreased after training. Serum osmolality following exercise were not different than the baseline or between the conditions. [Conclusion]Active drinking practices while exercising in a hot environment induced greater voluntary fluid intake and sweatloss. [Keyword]voluntary intake, rehydration, thermoregulation.

SAD PERSONS scale에 따른 자살 위험도 측정에 관한 예비적 연구

黃柱淵,孫鳳基 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2

The authors has thought whether we could utilize the SAD PERSONS scale in Korea or not. We studied 295 sicide attempters that were randomly sampled from those who visited HanGang Sacred Heart Hospital due to suicide attempt from March, 1981 to July, 1984. Each risk factor of the SAD PERSONS scale was tested with risk-rescue scores. It is suggested that of ten risk factors of the SAD PERSONS scale, the seven such as sex, depression, previous attempt, ethanol abuse, rational thinking loss, social supports lacking and no spouse can be utilized in Korea. On the other hand, the two factors such as age and organized plan have some discrepancies in our study, and so some modifications should be given according to Korean sociocultural background. And, further research is recommanded about the sickness factor.

Time course of changes in pyridoxal 5′-phosphate (vitamin B₆ active form) and its neuroprotection in experimental ischemic damage

Hwang, In Koo,Yoo, Ki-Yeon,Kim, Do Hoon,Lee, Bong-Hee,Kwon, Young-Guen,Won, Moo Ho Elsevier 2007 Experimental neurology Vol.206 No.1

<P><B>Abstract</B></P><P>In the present study, we investigated ischemia-induced changes of pyridoxal 5′-phosphate synthesizing enzyme and degrading enzyme and neuroprotective effects and roles of pyridoxal 5′-phosphate against ischemic damage in the gerbil hippocampal CA1 region. Pyridoxal 5′-phosphate oxidase and pyridoxal phosphate phosphatase immunoreactivities were changed in neurons up to 2?days after ischemia, while 4?days after ischemia their immunoreactivities were expressed in astrocytes. Pyridoxal 5′-phosphate oxidase immunoreactivity and its protein level were highest 12?h after ischemia, while those in pyridoxal phosphate phosphatase were highest 2?days after ischemia. Total activities of these enzymes were changed after ischemia, but specific activities of the enzymes were not altered. Treatment with pyridoxal 5′-phosphate into brains (4?μg/5?μl, i.c.v.) at 30?min before transient ischemia protected about 80% of CA1 pyramidal cells 4?days after ischemia and induced elevation of glutamic acid decarboxylase 67 immunoreactivity in the CA1 region. However, pyridoxal 5′-phosphate treatment into ischemic brains decreased GABA transaminase immunoreactivity in the CA1 region after ischemia. These results indicate that pyridoxal 5′-phosphate may be associated with the inhibitory discharge of GABA in the hippocampal CA1 neurons, and the increased level of GABA may protect hippocampal CA1 pyramidal cells from ischemic damage.</P>

Evaluation of Control Efficacy of a Potential Mycoherbicide, Sclerotinia sp., Isolate BWC98-105, Causing White Root Rot on Trifolium repens

Yeon Kyu Hong(홍연규),Jeong Nam Kim(김정남),Bong Choon Lee(이봉춘),Jae Bok Hwang(황재복),Seok-Bo Song(송석보),Sung-Tae Park(박성태),Min Gu Jeon(전민구),In Seob Kim(김인섭) 韓國雜草學會 2006 Weed&Turfgrass Science Vol.26 No.4

Hematoma-Related Nonhabitual Seizures during Subdural Electrode Monitoring

Hwang, Kyoung Jin,Joo, Eun Yeon,Hong, Seung Bong,Seo, Dae Won Korean Neurological Association 2018 Journal of Clinical Neurology Vol.14 No.3

Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population

Hwang, Joo-Yeon,Kim, Young Jin,Choi, Bo Youl,Kim, Bong-Jo,Han, Bok-Ghee Elsevier 2016 Bone Vol.84 No.-

<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>Calcaneal quantitative ultrasound has been recognized as a non-invasive method for evaluation of bone strength and prediction of osteoporotic fracture.</P> <P><B>Methods</B></P> <P>To extend a thorough genetic catalog for osteoporotic bone properties, we performed a genome-wide association study (rural cohort I, n=1895) of speed of sound (SOS) using the 1000 genome-based imputation in the discovery stage and then carried out <I>in silico</I> lookups (rural cohort II and III, n=2,967) and <I>de novo</I> genotyping (rural cohort IV, n=4,296) in the replication stage.</P> <P><B>Results</B></P> <P>In the combined meta-analysis (n=9,158), we identified a novel variant associated with SOS (rs2445771 in the <I>GLDN</I> gene, <I>P</I> =2.27×10<SUP>−9</SUP>) reaching genome-wide significance in the Korean population. We further demonstrated that allele-specific regulatory modifications found to be associated with functional enrichments by ENCODE annotations. Conclusion: Our findings could provide additional insights into understanding of genetic and epigenetic regulations on bone metabolism.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We performed a genome-wide meta analysis of SOS using the 1000 genome-imputed data. </LI> <LI> We identified a novel genetic variant associated with heel bone strength. </LI> <LI> We confirmed allele-specific epigenetic modifications. </LI> <LI> We replicated 10 previous European SOS signals in East-Asian subjects. </LI> </UL> </P>

RDBMS에 기반한 XML 문서에서 개별화된 노드 테이블을 이용한 String 매칭 기법

봉하익,황병연 가톨릭대학교 자연과학연구소 2006 자연과학논문집 Vol.27 No.-

1998년 W3C(World Wide Web Consortium)에서 XML(eXtensible Markup Language)이 제안된 이후 XML의 사용이 증가하였으며, 이에 따라 XML과 관련된 여러 분야에 대한 연구의 필요성이 증가하고 있다. 특히 XML로 표현된 문서에 대한 효율적인 저장, 검색, 관리를 위한 XML 문서 관리 시스템의 연구가 활발히 진행되고 있다. 이를 바탕으로 실제 많은 기관들이나 기업에서 XML 문서를 다량으로 사용하고 있음을 쉽게 확인할 수 있다. 이런 연구들 중 XRel은 많은 XML 문서 검색 기법의 비교 연구 대상이 되었으며, 이런 결과로 구조 조인 기법 같은 많은 기법들이 제시되고 있다. 이에 본 논문에서는 문서 검색 기법으로 XRel의 문자열 매칭 방식을 사용하되, 데이터베이스 내에서 Table 구조로 저장될 때 엘리먼트별로 나눠서 경로를 저장하는 방식을 제안한다. Since W3C proposed XML in 1998, XML documents have been widely spreaded in a lot of internet documents. Because of this, the need of research related with XML is increasing. Especially, it is being well performed to study XML management system for efficient storage, retrieval, and management with XML Documents. We can easily find lots of institutions and corporations are using a growing number of XML Documents. Among these studies, XRel is a representative study for XML management and has been become a comparative study. As a result, many techniques have been proposed such as structural join technique, ViST. In this study, we use string matching technique for retrieving XML document and propose path storage mechanism that stores XML document's tree paths starting with separate element in database table structure.

Late expression of Na⁺/H⁺ exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia

Hwang, In Koo,Yoo, Ki-Yeon,An, Sung-Jin,Li, Hua,Lee, Choong Hyun,Choi, Jung Hoon,Lee, Jae-Yong,Lee, Bong-Hee,Kim, Young-Myeong,Kwon, Young-Guen,Won, Moo-Ho Elsevier 2008 Experimental neurology Vol.212 No.2

<P><B>Abstract</B></P><P>Although acidosis may be involved in neuronal death, the participation of Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) in delayed neuronal death in the hippocampal CA1 region induced by transient forebrain ischemia has not been well established. In the present study, we investigated the chronological alterations of NHE1 in the hippocampal CA1 region using a gerbil model after ischemia/reperfusion. In the sham-operated group, NHE1 immunoreactivity was weakly detected in the CA1 region. Two and 3?days after ischemia/reperfusion, NHE1 immunoreactivity was observed in glial components, not in neurons, in the CA1 region. Four days after ischemia/reperfusion, NHE1 immunoreactivity was markedly increased in CA1 pyramidal neurons as well as glial cells. These glial cells were identified as astrocytes based on double immunofluorescence staining. Western blot analysis also showed that NHE protein level in the CA1 region began to increase 2?days after ischemia/reperfusion. The treatment of 10?mg/kg 5-(<I>N</I>-ethyl-<I>N</I>-isopropyl) amiloride, a NHE inhibitor, significantly reduced the ischemia-induced hyperactivity 1day after ischemia/reperfusion. In addition, NHE inhibitor potently protected CA1 pyramidal neurons from ischemic damage, and NHE inhibitor attenuated the activation of astrocytes and microglia in the ischemic CA1 region. In addition, NHE inhibitor treatment blocked Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger 1 immunoreactivity in the CA1 region after transient forebrain ischemia. These results suggest that NHE1 may play a role in the delayed death, and the treatment with NHE inhibitor protects neurons from ischemic damage.</P>