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RISS 인기검색어
- 검색키워드
- 저자 : Uwizeyimana, Cecile (검색결과 2 건)
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Uwizeyimana, Cecile Pukyong National University 2018 국내석사
Gwamegi is a famous traditional local food in Korea with an increasing consumption. To guarantee sustainable development of Gwamegi with improved quality, taste, and sanitation which satisfy consumer need, Gwamegi was produced from Pacific saury with a weight range of (50-100g) using RSM to maximize the response, and experimental design of 15 experimental treatments was used, the effect of humidity (30%, 40% and 50%), Temperature (14°C, 18°C, and 22°C), and time (24hrs, 36 hrs, and 48hrs) on weight loss (%), moisture content (%), TVBN, TMA, and sensory test was evaluated. Using SAS software program, RSREG procedure was performed. Statistical significance was observed at 95% confidential interval. To interpret the data, Maple 17 software was used to design 3-dimensional graph. The coefficient of regression (R2) and total mean for weight loss, moisture content, TVBN, TMA, fishy smell, Gwamegi smell, smell preference and appearance preference were 0.7422, 0.8104, 0.9360, 0.9495, 0.6983, 0.8385, 0.9636, 0.8181 and 37.30%, 24.21%, 11.29 mg%, 0.39 mg%, 1.85, 1.89, 1.89, 1.98, respectively. Variation for weight loss, moisture content, TVBN, and TMA ranged from 29.79-46.47%,16.8-34.0%,9.8-12.6 mg%, respectively and the score of fishy smell and gwamegi smell were from 1.4 (weak smell) - 2.1(medium smell), preference 1.6(like) – 2.3(neither like nor dislike), and appearance score varied between 1.6 -2.4(medium). Weight loss and moisture response were mostly affected by the order of temperature > humidity > time. TVBN and TMA increase were affected by time > humidity > temperature and humidity > temperature > time, respectively as well as sensory quality where an increase in time and temperature had a negative effect on Gwamegi preference than humidity. The best humidity for the overall evaluated sensory parameter was a humidity 30-45% with low time and temperature. RSM proved to be the effective method for optimizing Gwamegi processing.
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Jean Damascene Uwizeyimana Graduate School of Public Health, Yonsei Universit 2019 국내석사
ABSTRACT Introduction: Colistin has become a “last resort” antibiotic for the management of multidrug-resistant gram-negative bacteria. The disk diffusion method of susceptibility testing is commonly used in clinical microbiology since it is inexpensive and easy to perform, but is reported to be unreliable for colistin due to the characteristics of poor diffusion. Hence, improving colistin diffusion could improve the reliability of this method for testing colistin susceptibility. This study tests a modified Muller-Hinton agar in order to increase colistin disk diffusion. Methodology: Mueller-Hinton agar was modified by reducing the concentration of agar from 100% to 30% and adding 100 μg/ml of protamine. A total of 60 gram-negative clinical isolates consisting of Pseudomonas aeruginosa (PAE, n=27) and Acinetobacter calcoaceticus-baumannii complex (ACI, n=33) were tested. The results of disk diffusion were interpreted using MIC results determined by broth microdilution. Results: Using commercially available Muller-Hinton agar, there was no sufficient difference in inhibition zones between colistin susceptible and resistant strains to be clinical useful in laboratory settings, with a mean inhibition zone diameter of 7.2 ± 1.6 for resistance strains and 11.4 ± 0.6 for susceptible strains for both ACI and PAE. The sensitivity and specificity calculated based on MIC were high at the cutoff value of 10.5 mm, 94.7% and 95.1% respectively with the AUC of 0.979, (95% CI 0.939-1.000). After modifying agar concentration and adding protamine, we could appreciate a significantly larger difference between the resistant and susceptible strains for both ACI and PAE. The mean inhibition zone diameter was 8.4 ± 2.9 for resistant strains and 16.3 ± 0.9 for susceptible strains of both ACI and PAE. The sensitivity and specificity calculated based on MIC were high at the cutoff value of 13 mm, 94.7% and 100%, respectively with the AUC of 0.995, (95% CI 0.982-1.000). Conclusion: The study showed that the reduction of agar concentration from 100% to 30% together with the addition of protamine improved colistin diffusion, resulting in ability to accurately perform colistin susceptibility testing in a routine clinical microbiology laboratory setting.
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