A multitude of monuments: Finding and defending access to resources in third millennium BC Oman

Cable, Charlotte Marie Michigan State University 2012 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

How do different types of monuments and different monumental forms express social realities and inform larger social patterns? This dissertation research adds to this discussion from the perspective of the region best known for its ancient monuments: the Middle East. Known to its neighbors as the land of "Magan," the Oman Peninsula in the third millennium BC was the location of a dispersed yet well-integrated cultural tradition known as the Umm an-Nar. The people of Magan were trade partners with both the Mesopotamians to the west and the Indus to the north. Beginning in the late fourth millennium, the integration of coastal fishing communities and interior agricultural oases across the hyper-arid peninsula was matched by the development of a monumental tomb tradition spanning the length and breadth of Magan. In certain places – such as the Wadi al-Hijr – a second monumental tradition developed alongside the tomb tradition: that of the Umm an-Nar "tower." The combination of these two types of monuments provides a unique opportunity to consider the way(s) in which middle-range societies use monuments. This data set is a combination of published and unpublished excavation reports – particularly the towers of Bat by the American Expedition – and a survey designed and carried out for this project. The research progresses in several stages. Survey results indicate a high degree of clustering among the tombs, and occur within a variety of landscapes. I argue that the earliest ("Hafit") tombs mark access to resources, but are also mnemonics of regional social integration. Although the later ("Umm an-Nar") tombs do not mark resources, they reference the earlier tomb tradition, concentrate energy in the mortuary realm and on the monument itself, and thereby indicate a shift toward local (tomb-based) group identity. Excavations (led by the author) at the Hafit-Umm an-Nar transitional tower at Matariya demonstrate a change over time in the monumental aspects of the structure. This research argues that intensification limited access to underground and permanent water sources, and was used by local groups to leverage relative social, economic, and political position. Resource exclusivity flew directly in the face of ideologies of integration, visible in the Hafit tomb tradition, and Umm an-Nar people attempted to off-set this tension through an intensification of their mortuary practices. Contemporary monument types balance tensions between environments, individuals, kin and corporate groups. A diachronic study points to the ways in which structures of both types expand in monumentality. Together, synchronic and diachronic comparisons between different monument types indicate both growing friction between social groups, and a refusal to admit these divisions. Future research should investigate the tensions noted here.

Life in extreme environments: Lanthanide-based detection of bacterial spores and other sensor design pursuits

Cable, Morgan L California Institute of Technology 2010 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

Bacterial spores, or endospores, are produced by certain genera of bacteria under stress and are considered to be one of the most resilient forms of life on Earth. Detection of endospores is vital in areas ranging from bioburden reduction to homeland security. Rapid bacterial spore detection is achieved by targeting dipicolinic acid (DPA), a chemical marker unique to endospores. An improvement on the current bacterial spore detection assay based on sensitized lanthanide luminescence is presented through the implementation of a dipicolinate-specific Tb3+ receptor site. The use of a chelating ligand such as DO2A (1,4,7,10-tetraazacyclododecane- 1,7-bisacetate) can increase both the sensitivity and selectivity of the assay. The luminescent series of Ln(DO2A)(DPA)- complexes (Ln = Sm, Eu, Tb and Dy) is fully characterized in terms of structure, photophysics and stability, and the Tb(DO2A)+ binary complex in particular is investigated as a sensing complex for bacterial spores. The `ligand enhancement' observed in all cases improves dipicolinate binding affinity by approximately one order of magnitude over the lanthanide ion alone. Binding of the DO2A ligand also appears to generate a 'gadolinium break' effect, creating a discrepancy in binding affinity in the lanthanide series and rendering the terbium complex the most effective dipicolinate receptor site of all investigated. We have also extended the application of this receptor site design technology to the targeted detection of other aromatic analytes of biological relevance, such as salicylates and catecholamines. Our work indicates that construction of effective receptor site complexes is not governed by net electrostatic considerations, and that local charge variations from the ligand-induced perturbation of lanthanide electron density may play a significant role. This work sets the stage for the development of the next-generation terbium(macrocycle) complex for bacterial spore detection, with the aim of constructing a solid-state endospore microsensor for applications ranging from sterilization validation to life detection in extreme environments.

Investigation of Phosphorylation and Ligand Binding of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase

Cable, Jennifer Lynn The University of North Carolina at Chapel Hill 2011 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that localizes to focal adhesions upon integrin activation. FAK plays a key role in cell migration, cell cycle progression, and apoptosis. Because of its role in these processes, it is not surprising that FAK is also involved in tumor progression and metastasis. Overexpression of FAK often correlates with increased metastasis. The C-terminal focal adhesion targeting (FAT) domain of FAK is required for proper localization and subsequent activation of FAK. Phosphorylation of the FAT domain at Y926 by Src kinase is believed to delocalize FAK from focal adhesions and promote cell migration, angiogenesis, and tumor metastasis. Because of its role in such important processes, phosphorylation at Y926 is likely to be tightly regulated. Because the inherent conformation of Y926 is not favorable for Src recognition, phosphorylation of Y926 is thought to be regulated by changes in the conformation or dynamics of the region surrounding Y926. However, what regulates these conformational changes is unknown. In this study, we provide evidence that Src-mediated phosphorylation of Y926 is sensitive to pH in vitro and reveal a second site of Src-mediated phosphorylation in the FAT domain: Y1008. NMR studies of the FAT domain reveal pH-dependent changes in backbone dynamics in regions shown to be important for phosphorylation. In addition to understanding how phosphorylation is regulated, we also were interested in investigating how phosphorylation itself affects the characteristics of the FAT domain. To address this issue, we characterized several Y926 mutants of the FAT domain and determined that perturbation of Y926 affects paxillin binding. Therefore, it is likely that phosphorylation is incompatible with paxillin binding, which supports the hypothesis that phosphorylation delocalizes FAK from focal adhesions. Finally, we have investigated a possible interaction between the FAT domain and the protein talin. This interaction has been proposed as a secondary mechanism by which the FAT domain localizes FAK to focal adhesions. However, we were unable to detect an interaction under our conditions.

Experiments and Predictions with a Foil Thrust Bearing supported by Metal Mesh Screen

Cable, Travis Alexander Texas A&M University ProQuest Dissertations & Thes 2020 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

Modern micro-turbomachines (MTM) often employ light weight rotors operating at speeds in excess of 50 krpm. These turbomachines require radial and thrust bearings capable of handling high speeds, while also often operating in extreme environments (high and low temperature). Flexible structure air bearings, or foil bearings, provide an economical and clean (no oil or contamination) means of rotor support in this niche.To date, the most commonly utilized foil bearing is the bump-type foil bearing, which utilizes thin corrugated foil strips to support a smooth top foil on which hydrodynamic pressure builds. Despite its widespread use, each bump-foil is complex to build and model, requiring of extensive engineering knowledge and experience. As such, researchers continue to search for cheaper and less complex alternatives to the traditional bump-foil structure. Metal mesh, readily available and relatively cheap, is a viable option for radial foil bearings, but has yet to be investigated for use in foil thrust bearings.The dissertation presents the design and manufacture of a novel Rayleigh-step thrust foil bearing, whose top foil is supported by a circular layer (or layers) of compliant metal mesh screen. Static and dynamic load excitation tests (no rotor speed) with the prototype bearing reveal a structural stiffness which increases with the mass ratio of the mesh screen and decreases with the number of mesh layers used to support the top foil. Dynamic load excitation tests, up to 300 Hz., give a material loss factor γ ~ 0.2 for the mesh structure which is relatively unaffected by frequency. Foil bearings rely on structural damping from material hysteresis, and bump-type foil bearings exhibit a material loss factor which decreases quickly with an increasing excitation frequency, thus lending credence to metal mesh screen as a bearing support structure.Despite the promise of the novel Rayleigh-step foil thrust bearing, experiments with rotor speed failed several of the prototype top foils, the root-cause of which is attributed to the waviness of the metal mesh layers. This waviness unevenly bulges the thin top foil towards the spinning collar, causing solid contact between the metal top foil and collar before hydrodynamic pressure builds over the pads to separate the surfaces. The failure of several prototype foils points to the need of a robust coating for foil bearings, which can not be ignored by designers.Tests with a redesigned prototype, incorporating a circumferential taper and segmented pads, proved the bearing concept. A single pad bearing with a 55° arc extent and three layers of 40 OPI (openings per inch) mesh achieved a modest specific load of W/A = 35 kPa (per pad) at a rotor speed Ω = 40 krpm (ω·Rmid ~ 160 m/s). Further tests with a six-pad circumferentially tapered metal mesh foil thrust bearing (MMFTB) determined an ultimate load capacity of W/A ~ 25 kPa for Ω = 40 krpm. At this load capacity, the bearing temperature rise (measured via a thermocouple on the top foil backside) exceeded 110°C. The decreased load capacity for the six-pad bearing, as compared to the single-pad bearing, results from an uneven distribution of the thrust load between the six pads, as confirmed by temperature measurements on three of the top foil undersides. Similar to the Rayleigh-step top foil, the circumferentially tapered MMFTB suffered from taper height disparities between the pads, attributed to the waviness of the mesh, which is exacerbated by stacking multiple layers.In addition to the experimental work with compliant surface thrust bearings supported by metal mesh screen, the dissertation provides a thermo-elastohydrodynamic model, validated (to some degree) with cases from the literature. However, bearing drag torque measurements and predictions for a six-pad MMFTB do not agree well. A simple Couette-flow approximation for the bearing drag torque shows that the bearing would need to operate with a uniform film thickness (hconst = 2.7 μm) to produce the measured bearing drag torque (Texp = 180 N.mm). This minute film thickness is within typical combined roughness (rotor collar + pad roughness) values, and as such likely does not produce a full fluid film during operation. The simple analysis, along with posttest photographs of the thrust collar surface, corroborates the notion that the test bearing operated in the mixed-lubrication regime, with continuous sliding contact between asperities on the rotor collar and the pads coated with a sacrificial lubricant (MoS2).A further analysis with the current model compares the steady-state performance of a MMFTB with 3 sheets of 40 OPI mesh to that of a well-known BFTB geometry from the literature. Predictions show that the MMFTB has a nearly identical drag toque to that of the BFTB for loads 10 ≤ W/A ≤ 50 kPa and a large rotor speed Ω = 70 krpm (ω·Rmid ~ 279 m/s), although it has a slightly smaller film thickness (and likely a lower ultimate load capacity).Predictions with Ω = 70 krpm (ω·Rmid ~ 279 m/s) and a specific load W/A ≤ 30 kPa show that that the MMFTB operates slightly cooler than the BFTB (ΔTmax ~ 105 vs 115 K) when no cooling flow applies to the bearing. Applying cooling flow (0 ≤ Qcf ≤ 900 LPM) through the bearing center can decrease the peak film and top-foil temperatures by ~ 40°C, while decreasing the collar temperature by up to 10°C. For the bearing geometry utilized in the current predictions (see Table 14), a cooling flow rate Qcf ≥ 100 LPM fully supplies the pad leading edge, such that the bearing draws no fluid from the ambient air surrounding the bearing. Increasing the cooling flow beyond this point cools the pads via forced convection in the areas beneath the pad tapers (albeit little). For the MMFTB, the mesh screens under the pad and in the land section obstruct cooling flow, such that the cooling is less effective (when compared to the BFTB). Importantly, utilizing an aluminum collar (with a high thermal conductivity, κ = 130 W/m2K) limits the thermal gradient through the collar thickness to 5°C, reducing the possibility of thermal bending and a corresponding thermal runaway event.The dissertation adds to the archival literature on gas foil thrust bearings and provides a model for prediction of their performance. The failures detailed herein provide important lessons for foil bearing designers and researchers. Further research is needed to either qualify or disqualify metal mesh sheets as a viable underspring structure for gas foil thrust bearings, although the following document provides several cautions against their use.

Questions of work, class, gender, and style in the art and life of Gustave Caillebotte

Cable, Patrick Shaw Case Western Reserve University 2000 국내박사

Visualizing understandings online: Nontraditional pharmacy students' experiences with concept mapping

Green, Cable Thomas The Ohio State University 2003 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

Learning with technology is a challenge for both designers of and students in online degree programs. Due to new accreditation standards, pharmacists are returning to school. Pharmacy professionals, looking to update their skills, understandings and degree, find themselves overwhelmed with new information and are often without the capacity to incorporate it effectively into their practice. The implications for postsecondary education are profound. Information overload is the operative mode in which students and teachers now exist. Learning in this information rich environment requires different tools and pedagogical methods than are currently used in online learning environments. This dissertation is a report of how pharmacists can learn and communicate in new ways to become better practitioners and better learners. The practical work of developing and testing usable knowledge about online learning environments requires a fundamental understanding of the learning and technology experiences students bring with them to their learning environment, conceptual change processes, information visualization tools to help students visualize what they know, and collaborative learning pedagogies to facilitate sharing of students' understandings. This study explores the role of concept mapping as a tool to help students visualize what they know and to communicate their understandings with other students in an online learning community. While the pharmacists did concept map their understandings and acknowledged the benefits of working together, they did not share their concept maps. This study proposes a collaborative online learning community model for nontraditional students to explain these results. The model suggests the following. First, becoming an expert with a new tool takes time, hands on experience and may be a prerequisite to using the tool to learn and communicate in a learning community. Second, for students to move past public presentation of their ideas and into collaborative peer review of others' understandings, teachers must understand the decision making risk analysis nontraditional students employ. Third, building functional learning communities is difficult and takes time. Further research is needed to determine if these changes in how concept mapping is implemented and prioritized affect nontraditional students' sharing of understandings in online learning environments. GIF, QuickTime and WAV files are included.

Resilience in Black Mental Health Counselors

Cables, Ericka ProQuest Dissertations & Theses University of Miss 2022 해외박사(DDOD)

소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

Though resilience is a commonly studied variable in different disciplines, there is relatively little research on occupational settings. Researchers take various perspectives in defining resilience as a trait, process, and an outcome. Regardless of how it is defined, it is a vital protective factor for Black mental health counselors who may be significantly impacted by similar experiences, such as racism and racial discrimination, as the Black clients they serve. This dissertation study consisted of two studies utilizing the same data set. In the first study, psychometric properties of a new quantitative instrument, the Race-Based Resilience Scale (RBRS), was constructed to measure Race-Based Resilience (RBR) within a group of Black mental health counselors. The second study investigated group differences in Vicarious Traumatization (VT) and Race-Based Resilience (RBR) for Black mental health counselors with moderate and high levels of Racial Centrality (RC) using an independent samples t-test. Findings of the first study yielded a 14-item instrument with a three-factor solution (Self-Efficacy, Coping Mechanisms, and Multicultural and Social Justice Advocacy) that reflected high factor loading accounting for nearly 60% of the variance. For the second study, there was no significant difference in Vicarious Traumatization (VT) or Race-Based Resilience (RBR) scores for Black mental health counselors with moderate to high levels of Racial Centrality (RC).

(The) Genetic Relation Between Growth and Meat Quality Traits of Duroc Pig

Cabling, Meriam Miranda 순천대학교 2013 국내석사

The Genetic Relation Between Growth and Meat Quality Traits of Duroc Pig : 듀록종의 성장 및 육질 형질간 유전적 연관관계 규명

Meriam Miranda Cabling 순천대학교 대학원 2013 국내석사

This study estimates the heritability and the genetic and phenotypic correlations between growth and meat quality traits of Duroc pig. Data collected from 690 purebred Duroc pig for a period of 2009-2012 were used in the analysis. Variance components were obtained through the Restricted Maximum Likelihood procedures using Wombat and SAS program version 9.0. Animals were raised under the same management in five different breeding farms, namely: Kumbo, NongHyup, Wonsan, Samsung and RDA. The average daily gain, loin muscle area, back fat thickness, lean percent, carcass weight, and age to reach 90 kilograms (kg) body weight were the parameters used for growth traits. Meat quality traits included were pH, cooking loss, lightness, redness, yellowness, marbling score, moisture content, water holding capacity, carcass weight, meat color, shear force, sensory traits such as juiciness, flavor, tenderness, and palatability and fatty acids such as palmitic, stearic, oleic, linoleic and linolenic acid. Results showed that the pH value of meat was positively correlated (p<0.05) with age to reach 90 kg body weight (A90kg) (0.10) and longissimus muscle area (LMA) (0.12) parameters, but has no significant effects with other growth traits. The heritability estimates for meat quality traits varied largely from 0.01 to 0.79. Growth traits were moderate to highly heritable from 0.33 to 0.73. In addition, pH obtained low to high favorable genetic correlations with meat quality traits including cooking loss, lightness, redness, yellowness, carcass back fat, moisture content, water holding capacity, shear force and some fatty acids. Results of genetic correlations indicated that the selection for less back fat thickness could decrease pH, moisture content, water holding capacity, and fatty acid. Hence, to avoid further deterioration of pork characteristics, proper selection procedures should be considered.

(A ) Business Programing language for small computers

Tenny, Theodore Cabl 1982 국내박사