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RISS 인기검색어
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- 저자 : 조정기 (검색결과 32 건)
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마가복음의 내러티브 기독론적인 관점에서 본 예수의 자기-지칭 용어인 인자(The son of man) 연구
ABSTRACT Title : Study on the Son of Man, the self-naming of Jesus in the perspective on the narrative Christology of the gospel of Mark. This study is about "The Son of Man", the self-naming of Jesus in the narrative of the gospel of Mark. This term is used exclusively for Jesus only. Mark especially uses it related to the work of Jesus. The purpose of this study is to expose the term "the Son of Man" shows the work of redemption of Jesus as well as the identity of Jesus in the gospel of Mark. This study presented that the work of Jesus as "the Son of Man" was the achievement of the prophecies in the Old Testament through the research of biblical theology from the OT(Genesis 1, Psalm 8, Daniel 7) to the documents in early Judaism(Enoch 1, Ezra 4). It also tried to make exegesis of "the Son of Man" in Markan text, which explained how this term appeared concretely in the work of Jesus. Throughout this study, it was appeared that the work of Jesus as "the Son of Man" was the work of achievement of the prophecy of Isaiah and the liberation of mankind from constraint. It also demonstrated that the work of Jesus as "the Son of Man" was the achievement of the true meaning of the Sabbath and the work of the salvation of mankind by the redemptive death through the suffering. While the former studies about "the Son of Man" has focused on the name, this study has attempted to comprehend in relation with the OT focused on "the Son of Man" in the Markan narrative. This try was able to expose that the OT and the NT state not different but consistent story. Consequently, if one reads the gospel of Mark in this perspective - though it has been universally acknowledged that the gospel of Mark tells the achievement of "the salvation work" of Jesus- he is able to understand more apparently the achievement perspective of "the work of salvation" of Jesus appeared in the gospel of Mark. Key words : Son of Man, narrative reading, the achievement of gospel, redemptive death, liberation
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Poly (methyl methacrylate) (PMMA) have been used as a removable (orthodontic) dental base material. However, oral infection and unfavorable odor from micro-organism or biofilm on the dental materials have been issued in clinical situation. Here, we present ceria nanoparticle (CNP) incorporated PMMA (orthodontic resins) for inducing anti-adhesion effects to microbial organism. Sol-gel fabricated CNP had 20.7 nm diameter with 217.3 m2/g of surface area and 17.5 mV of zeta potential. When CNP was incorporated in PMMA (0, 0.25, 0.5, 1.0 and 2.0%) as additional filler and polymerized, mechanical strength and hardness were maintained. Candida albicans were less attached on the CNP-incorporated PMMA over CNP amount up to 95%. The mechanism of anti-adhesion ability to micro-organism was revealed due to increase of polar surface roughness and CNP’s anti-microorganism effect, not by surface roughness change. Within the limitation of above study and cytocompatibility against oral keratinocyte, CNP-incorporated PMMA orthodontic resin up to 2% showed a promising antimicrobial effect without dramatic decrease in mechanical properties. Polymethyl methacrylate (PMMA)는 치과교정용 구내 장치로 제작에 널리 사용되고 있지만, 미생물의 항부착성이 낮아 구강감염을 촉진시킬 염려가 있다. 본 연구에서는 향균력을 지닌 무기질 입자인 Cerium nanoparticle (CNP)를 orthodontic PMMA에 혼합하여 미생물 방지 접착 효과를 도입하고자 한다. 솔젤법을 이용하여 만든 CNP은 20.7 nm의 크기와 면적 217.3 m2/g 및 17.5 mV의 Zeta pontential을 가졌다. CNP을 혼합한 orthodontic PMMA (0, 0.25, 0.5, 1.0 및 2.0%)에서 3점 굽힘강도 시험 및 경도를 평가한 결과, 3점 굽힘강도와 경도가 유지됨을 관찰하였다. 향균성을 측정을 위해 Candida albicans을 시편위에 배양한 결과 CNP 농도가 높을수록 항부착 성질이 최대 60% 까지 관찰되었다. 이러한 항부착성질은 CNP의 향균력 보단 CNP 함입에 따른 표면에너지 증가와 관련이 있었다. 세포독성시험으로 CNP함유 orthodontic PMMA는 구강각질세포에 대한 독성은 관찰되지 않았다. 이렇게 개발된 CNP 함유 orthodontic PMMA는 의치 및 교정용 장치를 위한 미생물 접착 방지 치과 재료로 사용될 수 있을 것으로 사료 된다.
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조정기 Hanyang University 2016 국내박사
Purpose: Metastasis in prostate cancer (PCa) is associated with worse clinical outcomes. In addition, metastatic PCa can demonstrate progression to castration-resistant prostate cancer (CRPC) during androgen-deprivation therapy (ADT). In this study, we aimed to assess genetic variants in metastatic PCa and the relationship of single nucleotide polymorphisms (SNPs) associated with metastatic disease with progression to CRPC. Methods: We assessed genetic variation among 1000 patients with PCa with or without metastasis, using 242,221 SNPs on the custom HumanExome BeadChip v1.0 (Illuminam Inc.). We analyzed the time to CRPC in 104 of the 1000 patients who were treated with ADT. Genetic data were analyzed using unconditional logistic regression and odds ratios calculated as estimates of relative risk of metastasis. We identified SNPs associated with metastasis after correction for multiple testing, and analyzed the relationship between these SNPs and time to CRPC in metastatic PCa. Results: Analysis of exome genotypes revealed that 42 SNPs were significantly associated with metastatic PCa. The five polymorphisms among these 42 most strongly associated with metastatic PCa were rs2241714, rs143790069, rs72821581, rs75992542 and rs56350726. In addition, one of these SNPs, rs56350726 was significantly associated with time to CRPC in Kaplan-Meier analysis (Log rank test, p = 0.019). Conclusions: The five SNPs most strongly associated with metastatic PCa were rs2241714 rs143790069, rs72821581, rs75992542, rs56350726. One SNP in SLC28A3 (rs56350726) associated with metastatic PCa was also found to have a significant relationship with progression to CRPC among patients who were treated with hormone therapy.
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목적: HSP27은 종양 내에서 세포고사 조절, 면역반응 조절 및 약물 내성 등의 세포보호의 역할을 하며 c-FLIP은 death-inducing signal complex (DISC)에서 Fas로 매개되는 세포고사를 억제하는 물질로 DISC의 caspase-8의 활성화를 억제시켜 세포고사를 막는 것으로 알려져 있다. 본 연구는 면역화학적 방법을 이용하여 HSP27과 c-FLIP의 발현과 전립선암의 Gleason score sum(GSS)와 병기 사이의 관계에 대해 조사하였다. 대상 및 방법: 2004년 5월부터 2010년 4월까지 전립선암으로 근치적전립선절제술을 시행 받은 64례와 호르몬불응성전립선암으로 인한 배뇨증상의 완화를 위해 경요도전립선절제술을 시행받은 19례 총 83례의 환자를 대상으로 하였다. HSP27과 c-FLIP의 면역조직화학 염색에 발현되는 것을 관찰하였으며, 5% 범위 이하에서 반응을 보인 경우 1, 5-50%의 범위에서 반응을 보인 경우 2, 50%이상의 범위에서 반응을 보인 경우 3으로 표시하였다. 국소적으로 반응을 보인 경우 0.5로 수치화 하여 평가하였다. 결과: GSS 4, 5, 6, 7, 8, 9, 10에 따른 HSP27의 양성반응률은 0, 25, 12.5, 60, 100, 95.83, 100 % 였으며 (p<0.001), 반응점수의 평균은 0, 0.25, 0.13, 0.82, 2.13, 2.75, 3 이었다. (p<0.001) 병리학적 병기 T1, T2, T3, T4에 따른 HSP27의 양성반응률은 50, 50.68, 88.46, 90.91 %로 나타났으며 (p=0.001) 반응점수의 평균은 1, 1.01, 2.15, 2.64 이었다. (p<0.001) GSS 4, 5, 6, 7, 8, 9, 10에 따른 c-FLIP의 발현은 양성반응률 0, 0, 37.5, 88, 93.75, 100, 100%로 나타났으며(p<0.001) 반응점수의 평균은 0, 0, 0.63, 1.08, 1.44, 2.33, 3 이었다. (p<0.001) 병리학적 병기 T1, T2, T3, T4에 따른 c-FLIP의 양성반응률은 50, 65.91, 100, 100 % 였으며 (p<0.001) 반응점수의 평균은 1, 0.95, 1.92, 2.36 이었다. (p<0.001) GSS와 HSP27, c-FLIP의 관계는 HSP27이 c-FLIP에 비해 GSS와 연관성이 높았다. (r=0.814, 0.776) 병리학적 병기에서도 HSP27이 c-FLIP에 비해 연관성이 높았다. (r=0.592, 0.554) 결론: 전립선암에서 GSS 및 병리학적 병기가 높을수록 HSP27 양성반응 정도와 반응점수가 높았다. HSP27의 발현은 GSS 및 전립선암의 병기와 관계가 있었다. 병리학적 병기가 높을수록 c-FLIP 양성반응 정도와 반응점수가 높았다. HSP27이 c-FLIP보다 병리학적 병기 및 GSS와 상관관계가 높았다.
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